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WDFY3 encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. Additionally we are shipping and many more products for this protein.
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Chicken Polyclonal WDFY3 Primary Antibody for WB - ABIN2784358
Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005
Human Monoclonal WDFY3 Primary Antibody for ELISA, WB - ABIN949075
Orosco, Ross, Cates, Scott, Wu, Sohn, Pleasure, Pleasure, Adamopoulos, Zarbalis: Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. in Nature communications 2014
we demonstrate that normally ALFY attenuates the canonical Wnt (show WNT2 Antibodies) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 (show DVL3 Antibodies) and not of Dvl1 (show DVL1 Antibodies) or Dvl2 (show DVL2 Antibodies).
ALFY binds selectively to LC3C (show MAP1LC3C Antibodies) and the GABARAPs through a LC3 (show MAP1LC3A Antibodies)-interacting region in its WD40 domain (show DCAF12L2 Antibodies).
increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others
Data suggest that p62 (show GTF2H1 Antibodies) and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy.
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
Alfy might target cytosolic protein aggregates for autophagic degradation.
Alfy translocalization likely is involved in the pathogenesis of amyotrophic lateral sclerosis.
Wdfy3 is important in regulating neural progenitor divisions, neural migration, cerebral expansion and functional organization in the developing brain. Loss-of-function leads to pathological changes characteristic of autism spectrum disorders.
gene expression profiling; in situ hybridization analysis revealed that the expressed BWF1 mRNA was restricted to the marginal region both in E14 (show NPAT Antibodies) and E16 (show SLC7A5 Antibodies) embryonic brain, but became diffuse after birth
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.
WD repeat and FYVE domain containing 3
, WD repeat and FYVE domain-containing protein 3
, autophagy-linked FYVE protein
, beach domain, WD repeat and FYVE domain-containing protein 1
, galactosyltransferase 3 beta 1, 4