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anti-WW Domain Containing Transcription Regulator 1 (WWTR1) Antibodies

WWTR1 encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. Additionally we are shipping WWTR1 Proteins (5) and WWTR1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WWTR1 25937 Q9GZV5
WWTR1 97064 Q9EPK5
WWTR1 295062  
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Top anti-WWTR1 Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-WWTR1 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB WWTR1 Antibody (C-term) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the WWTR1 antibody detected the WWTR1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western Blot: TAZ Antibody [ABIN153163] - Western blot analysis of TAZ in MDCK cells using ABIN153163 at 1:250 dilution. 0.1 mg Log in to see 5 to 7 Days
$381.94
Details
Human Rabbit Un-conjugated ChIP, ICC, IF, IHC (p), IP, SimWes, WB Detection of ABIN258561 protein using ABIN258561 on HEK 293 cell lysate. Simple Western: TAZ/WWTR1 Antibody [ABIN2585619] - Simple Western lane view shows a specific band for TAZ in 0.5 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.1 mL Log in to see 5 to 7 Days
$447.56
Details
Human Rabbit Un-conjugated WB WWTR1 Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the WWTR1 antibody detected the WWTR1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC204082 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-WWTR1 antibody (ABIN2454926), and then analyzed by flow cytometry. Anti-WWTR1 mouse monoclonal antibody (ABIN2454926) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY WWTR1 (RC204082). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IHC, WB Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-WWTR1 mouse monoclonal antibody. (ABIN2455017) HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY WWTR1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-WWTR1. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC204082 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-WWTR1 antibody (ABIN2454960), and then analyzed by flow cytometry. Anti-WWTR1 mouse monoclonal antibody (ABIN2454960) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY WWTR1 (RC204082). 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details

WWTR1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine)
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Rat (Rattus)


Top referenced anti-WWTR1 Antibodies

  1. Human Polyclonal WWTR1 Primary Antibody for EIA, WB - ABIN955592 : Remue, Meerschaert, Oka, Boucherie, Vandekerckhove, Sudol, Gettemans: TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner. in FEBS letters 2010 (PubMed)
    Show all 5 references for ABIN955592

  2. Cow (Bovine) Polyclonal WWTR1 Primary Antibody for WB - ABIN2779708 : Hong, Hwang, McManus, Amsterdam, Tian, Kalmukova, Mueller, Benjamin, Spiegelman, Sharp, Hopkins, Yaffe: TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. in Science (New York, N.Y.) 2005 (PubMed)

More Antibodies against WWTR1 Interaction Partners

Zebrafish WW Domain Containing Transcription Regulator 1 (WWTR1) interaction partners

  1. Yap (show YAP1 Antibodies)/Taz (show TAZ Antibodies)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.

  2. Taz (show TAZ Antibodies) is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.

  3. Taz (show TAZ Antibodies)-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles

  4. When transcriptional coactivators Yap (show YAP1 Antibodies) and Taz (show TAZ Antibodies) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.

  5. TAZ (show TAZ Antibodies) has a critical role in osteoblast differentiation in vivo

Human WW Domain Containing Transcription Regulator 1 (WWTR1) interaction partners

  1. The activity of the YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) transcriptional coactivators, was found to be regulated by metabolic pathways, such as aerobic glycolysis and mevalonate synthesis, and by the nutrient-sensing LKB1 (show STK11 Antibodies)-AMPK (show PRKAA1 Antibodies) and TSC (show SLC12A3 Antibodies)-mTOR (show FRAP1 Antibodies) pathways. (Review)

  2. Over expression of TAZ (show TAZ Antibodies) was associated with abnormal expression of beta-catenin (show CTNNB1 Antibodies), which is correlated with poor prognosis of patients with adenocarcinoma of the esophagogastric junction

  3. Our findings emphasize the tumorigenic role of TAZ (show TAZ Antibodies) and may serve as the basis for new treatment strategies.

  4. Immortalized fibroblasts conditionally expressing active YAP (show YAP1 Antibodies) or TAZ (show TAZ Antibodies) mutant proteins overcome soft matrix limitations on growth and promote fibrosis

  5. Results revealed that TAZ (show TAZ Antibodies) is a differentially expressed molecule in human hepatocellular carcinoma (HCC (show FAM126A Antibodies)) suggesting it as an important regulator, TAZ (show TAZ Antibodies) might be as a new diagnostic biomarker in HCC (show FAM126A Antibodies).

  6. Results show TAZ (show TAZ Antibodies) functioned as an oncogene (show RAB1A Antibodies) and promoted pancreatic cancer epithelial-mesenchymal transition and progression.

  7. this article summarizes the current understanding of the biological functions of YAP (show YAP1 Antibodies) and TAZ (show TAZ Antibodies), and how the regulation of these two proteins can be disrupted in cancer.[Review][

  8. TAZ (show TAZ Antibodies) inhibits temozolomide induced apoptosis via upregulation of MCL-1 (show MCL1 Antibodies) (myeloid cell leukemia 1) and high expression of TAZ (show TAZ Antibodies) predicts a poor prognosis for GBM patients

  9. TAZ (show TAZ Antibodies) and YAP (show YAP1 Antibodies) are differentially regulated by hypoxia in cancer cells

  10. Overexpression of TAZ (show TAZ Antibodies) in neuroblastoma (show ARHGEF16 Antibodies) BE(2)-C cells increases cell proliferation, self renewal and colony formation. TAZ (show TAZ Antibodies) knockdown reverses this. TAZ (show TAZ Antibodies) promotes cell proliferation and tumorigenicity by up-regulating CTGF (show CTGF Antibodies) and PDGF (show PDGFA Antibodies)-beta genes.

Mouse (Murine) WW Domain Containing Transcription Regulator 1 (WWTR1) interaction partners

  1. Expression of TAZ (show TAZ Antibodies) promotes embryonic neural stem cell maintenance by enhancing stemness of neural stem cells during mammalian brain development.

  2. Tead2 (show TEAD2 Antibodies) transcription factors are crucial regulators of the cellular distribution of Yap (show YAP1 Antibodies) and Taz (show TAZ Antibodies), and together they control the expression of genes critical for EMT (show ITK Antibodies) and metastasis.

  3. findings uncover important roles for Yap (show YAP1 Antibodies) and Taz (show TAZ Antibodies) in cranial neural crest diversification and development

  4. Study discovered that YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) are bona fide downstream effectors of the alternative Wnt (show WNT2 Antibodies) signaling pathway.

  5. Hippo signalling effectors, YAP (show YAP1 Antibodies) and TAZ (show TAZ Antibodies), promote both the proliferation of intestinal stem/progenitor cells and their differentiation into goblet cells.

  6. This study identifies a novel mechanism of TAZ (show TAZ Antibodies) regulation by YAP (show YAP1 Antibodies), which has significant implications for our understanding of Hippo pathway regulation, YAP (show YAP1 Antibodies)-isoform specific signaling, and the role of these proteins in cell proliferation, apoptosis, and tumorigenesis

  7. Disrupting Yap (show YAP1 Antibodies)/Taz (show TAZ Antibodies) activities enhances Ret (show RET Antibodies) pathway activity and contributes to pathogenesis of lower urinary tract defects

  8. Immortalized fibroblasts conditionally expressing active YAP (show YAP1 Antibodies) or TAZ (show TAZ Antibodies) mutant proteins overcome soft matrix limitations on growth and promote fibrosis

  9. YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) regulate transcriptional elongation from the enhancer elements by recruiting the Mediator complex and promoting phenotypes of overgrowth and tumorigenesis

  10. A YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies)-miR (show MLXIP Antibodies)-130/301 molecular circuit exerts systems-level control of fibrosis in a network of diseases and physiologic conditions

WWTR1 Antigen Profile

Protein Summary

This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described.

Gene names and symbols associated with WWTR1

  • WW domain containing transcription regulator 1 (wwtr1) antibody
  • WW domain containing transcription regulator 1 (WWTR1) antibody
  • WW domain containing transcription regulator 1 (Wwtr1) antibody
  • 2310058J06Rik antibody
  • 2610021I22Rik antibody
  • C78399 antibody
  • Taz antibody
  • WWTR1 antibody

Protein level used designations for WWTR1

WW domain containing transcription regulator 1 , WW domain-containing transcription regulator protein 1 , taz , WW domain-containing transcription regulator protein 1-like , transcriptional co-activator with PDZ-binding motif , transcriptional coactivator with PDZ-binding motif , transcriptional coactivator with PDZ binding motif , transcriptional co-activator with PDZ-binding motif (TA)Z , transcriptional co-activator with PDZ-binding motif (TAZ)

GENE ID SPECIES
496155 Xenopus laevis
568008 Danio rerio
100050661 Equus caballus
100401831 Callithrix jacchus
100437619 Pongo abelii
100493170 Xenopus (Silurana) tropicalis
100522573 Sus scrofa
100592028 Nomascus leucogenys
25937 Homo sapiens
609743 Canis lupus familiaris
614786 Bos taurus
97064 Mus musculus
295062 Rattus norvegicus
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