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anti-Human SIN3A Antibodies:
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Human Polyclonal SIN3A Primary Antibody for ChIP, ICC - ABIN269451
Feng, Sangster-Guity, Stone, Korczeniewska, Mancl, Fitzgerald-Bocarsly, Barnes: Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. in Journal of immunology (Baltimore, Md. : 1950) 2010
Show all 3 Pubmed References
Human Polyclonal SIN3A Primary Antibody for ChIP, WB - ABIN2668357
Chalei, Sansom, Kong, Lee, Montiel, Vance, Ponting: The long non-coding RNA Dali is an epigenetic regulator of neural differentiation. in eLife 2014
the FOXN3 (show FOXN3 Antibodies)-NEAT1-SIN3A complex promotes epithelial-to-mesenchymal transition and invasion of breast cancer cells in vitro as well as dissemination and metastasis of breast cancer in vivo
Haploinsufficiency of SIN3A causes mild intellectual disability by affecting the development of cortical integrity.
Two novel translocations leading to the inactivation of RUNX1 (show RUNX1 Antibodies) and its partners SIN3A and TCF12 (show TCF12 Antibodies) in myeloid leukemia (show BCL11A Antibodies).
Study suggests a lack of association of SIN3A gene sequence variants with azoospermia caused by Sertoli cell-only syndrome in humans.
down regulation of miR (show MLXIP Antibodies)-202 increased the expression of its target Mxd1 (show MXD1 Antibodies), followed by Mxd1 (show MXD1 Antibodies) recruitment to the Sin3A repressor complex and through its dimerization with Max, and increased repression of Myc (show MYC Antibodies)-Max target proteins.
protein pairs significantly correlated with an increased risk of death in non-small cell lung cancer: mSin3A with p16 (show CDKN2A Antibodies), and c-Myc (show MYC Antibodies) with mSinA
Aberrantly expressed miR (show MLXIP Antibodies)-210 regulates human U251 glioma cells apoptosis and proliferation partly through directly down-regulating SIN3A protein expression.
Bone-marrow-specific deletion of Sin3a, indicated that Sin3a-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis.
SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor (show AHR Antibodies).
EBNA3C binds strongly to BATF/IRF4 (show IRF4 Antibodies)/SPI1 (show SPI1 Antibodies)/RUNX3 (show RUNX3 Antibodies) sites to enhance transcription and recruits RBPJ (show RBPJ Antibodies)/Sin3A- and REST/NRSF (show REST Antibodies)-repressive complexes to repress p14(ARF (show CDKN2A Antibodies)) and p16(INK4A (show CDKN2A Antibodies)) expression
The co-repressor protein Sin3a is crucial for lung endoderm development. Loss of Sin3a in early foregut endoderm led to a specific and profound defect in lung development with lung buds failing to undergo branching morphogenesis and progressive atrophy of the proximal lung endoderm with complete epithelial loss at later stages of development.
Taken together, Fam60a is an essential core subunit of a variant Sin3a-Hdac (show HDAC3 Antibodies) complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation.
TGF-beta1 (show TGFB1 Antibodies)-induced inhibition of PPARgamma (show PPARG Antibodies) transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3 (show SMAD3 Antibodies), mSin3A and HDAC1 (show HDAC1 Antibodies) at the PPARgamma (show PPARG Antibodies) promoter.
Sin3a mRNA is recruited during maturation and that inhibiting its recruitment not only inhibits development beyond the 2-cell stage but also compromises the fidelity of reprogramming gene expression
Report role of myocardial mSin3A/HDAC1 (show HDAC1 Antibodies)/2 complex in mediating the beneficial effects of exercise in diabetic cardiomyopathy.
Treatment with GlcN, in contrast, inhibits LPS (show TLR4 Antibodies)-ind inflammation and decreased LPS (show TLR4 Antibodies)-mediated recruitment of OGT (show OGT Antibodies), mSin3A, and HDACs.
Within the male germline, Sin3a is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of differentiating spermatogonia and subsequent spermatogenic processes.
Sin3A-deleted testes exhibit a Sertoli-cell only phenotype, consistent with the absolute requirement for Sin3A in germ cells' development and/or viability.
Sin3 has an important role in the regulation of cell cycle kinetics of the myogenic progenitor cell population
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
SIN3 homolog A, transcription regulator
, transcriptional co-repressor Sin3A
, paired amphipathic helix protein Sin3a
, SIN3 homolog A, transcription regulator (yeast)
, paired amphipathic helix protein Sin3a-like
, SIN3 transcription regulator homolog A
, histone deacetylase complex subunit Sin3a
, transcriptional corepressor Sin3a
, transcriptional regulator, SIN3A
, transcriptional regulator, SIN3 yeast homolog A