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Browse our PRKAA1 Proteins (PRKAA1)

Full name:
Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit Proteins (PRKAA1)
On are 6 Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Proteins from 4 different suppliers available. Additionally we are shipping PRKAA1 Antibodies (291) and PRKAA1 Kits (21) and many more products for this protein. A total of 327 PRKAA1 products are currently listed.
AI194361, AI450832, AL024255, AMPK, AMPK1, AMPKa1, AMPKalpha1, C130083N04Rik, cb116, im:7154392, PRKAA1, sb:cb130, wu:fa94c10
list all proteins Gene Name GeneID UniProt
PRKAA1 108080  
PRKAA1 5562 Q13131
Rat PRKAA1 PRKAA1 65248 P54645

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PRKAA1 Proteins (PRKAA1) by Origin

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More Proteins for PRKAA1 Interaction Partners

Mouse (Murine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Data show that metformin may protect against ciaplatin induced acute kidney injury (AKI) through stimulating AMPKalpha (show GRK4 Proteins) activation.

  2. m(6)A methylation status influences RNA, AMPKalpha1 phosphorylation and dysfunctional adipose tissue induced by high-fat diet

  3. phosphorylation of PLIN2 (show PLIN2 Proteins) is dependent on AMPK and occurs after the interaction of PLIN2 (show PLIN2 Proteins) with the chaperone-mediated autophagy chaperone HSPA8/Hsc70 (show HSPA8 Proteins).

  4. Ngb (show NGB Proteins) functions as a metabolic regulator and enhances cellular anabolism through the inhibition of AMPK signaling.

  5. findings indicate that miR (show MLXIP Proteins)-291b-3p promotes hepatic lipogenesis by suppressing AMPKalpha1 expression and activity, indicating the therapeutic potential of miR (show MLXIP Proteins)-291b-3p inhibitors in fatty liver disease.

  6. Adiponectin abrogated these effects. From a mechanistic standpoint, the effects of adiponectin on MP release and molecular signaling occurred at least in part through the AMPK, Akt and NFkappaB pathways.

  7. The authors unexpectedly uncover a ROQUIN (show RC3H1 Proteins)-AMPK metabolic signaling nexus essential for selectively promoting T follicular helper cell responses.

  8. Rapid activation of AMPK was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 (show STK11 Proteins) activation but not increased intracellular AMP (show TMPRSS5 Proteins) levels or CaMKKbeta activation.

  9. PDE4B (show PDE4B Proteins) phosphorylated by AMPK at Ser304 is important for activation.

  10. Deletion of the AMPK alpha-subunits improves oral but not intraperitoneal glucose tolerance.

Cow (Bovine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).

  2. The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.

  3. Nitrated oleic acid activates AMPK in endothelial cells.

  4. Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (show SLC12A1 Proteins) involves activation of AMPK.

  5. Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.

  6. the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (show NOS3 Proteins)

Human Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK exerts multiple actions on TGF-beta (show TGFB1 Proteins) signaling and supports that AMPK can serve as a therapeutic drug target for breast cancer

  2. Despite differences in total work done, low-volume INT and CON (show DISP1 Proteins) 'all-out' cycling, matched for exercise duration, provides a similar stimulus for the induction of mitochondrial and angiogenic cell signalling pathways in trained skeletal muscle.

  3. Suggest that fenoterol inhibited AICAR-induced AMPK alpha1 activation and TNF-alpha release through beta-arrestin-2 in THP-1 cells.

  4. Down-regulation of miR (show MLXIP Proteins)-137 ameliorates high glucose-induced injury in HUVEC cells by overexpression of AMPKa1, leading to increasing cellular reductive reactions and decreasing oxidative stress.

  5. human cells were infected with lentiviruses expressing shRNA targeting both alpha1 and alpha2 AMPK subunits. AMPK activation inhibits Gli1 (show GLI1 Proteins)-driven proliferation and that this effect is linked to Ser408 phosphorylation, which represents a key metabolic checkpoint for Hh signaling.

  6. AMPK actions extend well beyond its energy-regulating role, and it appears to possess an essential role in regulating fibrosis of the myocardium. (Review)

  7. when treated with exendin-4 plus AICAR (show ATIC Proteins), an AMPK activator, cell apoptosis increased with higher ratio of phosphorylayed-AMPK/AMPK, lower ratio of phosphorylated-mTOR/mTOR (show FRAP1 Proteins) and higher expression of cleaved caspase-3 (show CASP3 Proteins) than those in exendin-4 alone group

  8. binding between AMPK and b-catenin occurs in the cytosolic fraction, and therefore concluded that the cancer cell antiproliferative effects of selenium are mediated by a GSK3b-independent AMPK/b-catenin pathway

  9. The protective effect of ampelopsin against hyperglycemia-induced cell damage, which functions by targeting autophagy via AMPK activation, makes it a promising pharmacological treatment for type-2 diabetes.

  10. Metformin inhibits PGE2-induced CYP19A1 (show CYP19A1 Proteins) mRNA expression/aromatase (show CYP19A1 Proteins) activity via AMPK activation in endometriotic stromal cells.

Zebrafish Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.

Xenopus laevis Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa (show SLC34A1 Proteins) oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.

  2. NDPK-A (show NME1 Proteins) exists in a functional cellular complex with AMPK (show PRKAA2 Proteins) and CFTR (show CFTR Proteins) in airway epithelia, and NDPK-A (show NME1 Proteins) catalytic function is required for the AMPK (show PRKAA2 Proteins)-dependent regulation of CFTR (show CFTR Proteins)

Pig (Porcine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK-mTOR (show FRAP1 Proteins)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  2. Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (show MYLIP Proteins)-1285 and thus activating AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).

  3. L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.

  4. AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.

  5. AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.

  6. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (show MAPK1 Proteins)/TSC2/mTOR (show FRAP1 Proteins) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  7. AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.

  8. AMPK functions to inhibit IGF-I (show IGF1 Proteins)-stimulated PI3K pathway activation through stimulation of IRS-1 (show IRS1 Proteins) serine 794 phosphorylation.

  9. acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation

PRKAA1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with PRKAA1

  • protein kinase, AMP-activated, alpha 3 catalytic subunit (Prkaa3)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (prkaa1)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1)
  • AI194361 protein
  • AI450832 protein
  • AL024255 protein
  • AMPK protein
  • AMPK1 protein
  • AMPKa1 protein
  • AMPKalpha1 protein
  • C130083N04Rik protein
  • cb116 protein
  • im:7154392 protein
  • PRKAA1 protein
  • sb:cb130 protein
  • wu:fa94c10 protein

Protein level used designations for PRKAA1

protein kinase, AMP-activated, alpha 3 catalytic subunit , protein kinase, AMP-activated, alpha 1 catalytic subunit , 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein , 5'-AMP-activated protein kinase catalytic subunit alpha-1 , AMPK-activated protein kinase alpha-1 subunit , 5'-AMP-activated protein kinase alpha 1 catalytic subunit , 5'-AMP-activated protein kinase, catalytic alpha-1 chain , ACACA kinase , AMP -activate kinase alpha 1 subunit , AMP-activated protein kinase, catalytic, alpha-1 , AMPK alpha 1 , AMPK subunit alpha-1 , HMGCR kinase , acetyl-CoA carboxylase kinase , hydroxymethylglutaryl-CoA reductase kinase , tau-protein kinase PRKAA1 , AMPK alpha-1 chain , AMP-activated protein kinase, alpha 1 catalytic subunit , ampka1 , 5'-AMP-activated protein kinase alpha-1 catalytic subunit , AMPKalpha1 , 63 kDa subunit , AMPK 63 kDa subunit

108080 Mus musculus
100009710 Equus caballus
100034740 Meleagris gallopavo
100145520 Xenopus (Silurana) tropicalis
100294665 Ovis aries
540404 Bos taurus
5562 Homo sapiens
65248 Rattus norvegicus
105787 Mus musculus
100001198 Danio rerio
495290 Xenopus laevis
427185 Gallus gallus
479351 Canis lupus familiaris
100145903 Sus scrofa
100174304 Pongo abelii
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