Browse our PRKAA1 Proteins (PRKAA1)

On www.antibodies-online.com are 8 Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Proteins from 4 different suppliers available. Additionally we are shipping PRKAA1 Antibodies (318) and PRKAA1 Kits (20) and many more products for this protein. A total of 355 PRKAA1 products are currently listed.
Synonyms:
AI194361, AI450832, AL024255, AMPK, AMPK1, AMPKa1, AMPKalpha1, C130083N04Rik, cb116, im:7154392, PRKAA1, sb:cb130, wu:fa94c10
list all proteins Gene Name GeneID UniProt
PRKAA1 108080  
PRKAA1 5562 Q13131
Rat PRKAA1 PRKAA1 65248 P54645

PRKAA1 Proteins (PRKAA1) by Origin

More Proteins for PRKAA1 Interaction Partners

Mouse (Murine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. The metformin-rescued P23H rhodopsin was still intrinsically unstable and led to increased structural instability of the rod outer segments. These data suggest that improving the traffic of misfolding rhodopsin mutants is unlikely to be a practical therapy, but also highlights the potential of altering translation through AMPK to improve protein function in other protein misfolding diseases

  2. Mechanistically, miR (show MLXIP Proteins)-499 directly targets Fnip1, an AMP-activated protein kinase (AMPK (show PRKAA2 Proteins))-interacting protein that negatively regulates AMPK, a known activator of PGC-1alpha. This miR (show MLXIP Proteins)-499/Fnip1/AMPK circuit can serve as a mechanism to couple muscle fiber type and mitochondrial function.

  3. dopamine is coupled to AMPK activation, which provides a substantial anti-inflammatory and bioenergetic advantage and reduces the severity of endotoxin-induced acute lung injury.

  4. AMPKalpha1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development.

  5. mitochondrial dysfunction triggers LKB1 (show STK11 Proteins)-mediated AMPK activation, which stimulates Sirt2 (show SIRT2 Proteins) phosphorylation, leading to activation of mTOR (show FRAP1 Proteins)-RAPTOR (show RPTOR Proteins) and Glut1 (show SLC2A1 Proteins)-mediated glucose uptake.

  6. AMPK-dependent metabolic repair mechanisms are important for mitigating lung injury.

  7. these data demonstrated that LKB1 (show STK11 Proteins)/AMPK signaling pathway activation improved the survival of diabetic mice complicated with endotoxemia. Thus, LKB1 (show STK11 Proteins)/AMPK signaling pathway may serve as a potentially useful therapeutic target for severe infection in diabetic patients.

  8. We confirmed that procyanidins suppressed acute hyperglycemia with an oral glucose tolerance test in a dose-dependent manner.procyanidins, especially cinnamtannin A2, significantly ameliorate postprandial hyperglycemia at least in part by promoting GLUT4 (show SLC2A4 Proteins) translocation to the plasma membrane by activating both insulin (show INS Proteins)- and AMPK-signaling pathways.

  9. These findings demonstrate that the AMPK-TBC1D1 (show TBC1D1 Proteins) signaling nexus interacts with the PKB (show AKT2 Proteins)-mTOR (show FRAP1 Proteins) pathway via IGF1 (show IGF1 Proteins) secretion, which consequently controls expression of lipogenic genes in the adipose tissue

  10. AMPKa1 deficiency impairs autophagy-mediated monocyte differentiation and decreases monocyte/macrophage survival

Cow (Bovine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).

  2. The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.

  3. Nitrated oleic acid activates AMPK in endothelial cells.

  4. Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (show SLC12A1 Proteins) involves activation of AMPK.

  5. Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.

  6. the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (show NOS3 Proteins)

Human Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. The metformin-rescued P23H rhodopsin was still intrinsically unstable and led to increased structural instability of the rod outer segments. These data suggest that improving the traffic of misfolding rhodopsin mutants is unlikely to be a practical therapy, but also highlights the potential of altering translation through AMPK to improve protein function in other protein misfolding diseases

  2. These results suggest that the LKB1 (show STK11 Proteins)-AMPK-FoxO1 (show FOXO1 Proteins) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.

  3. this study shows taht AMPK reduces abnormal inflammatory responses and cellular senescence, which implicates as a potential therapeutic target for chronic obstructive pulmonary disease/emphysema

  4. Salusin-beta mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway.

  5. These findings identify a key mechanism of tolerance to Ras-Raf (show RAF1 Proteins) pathway inhibitors and suggest that blocking either AMPK or autophagy in combination with these targeted inhibitors could increase tumor regression and decrease the likelihood of eventual recurrence.

  6. the Runx2 (show RUNX2 Proteins) knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha (show GRK4 Proteins)), the sensor of cellular metabolism. Importantly, the Runx2 (show RUNX2 Proteins) knockdown in bone-derived cells resulted in increased sensitivity to both Erk1/2 inhibition and AMPKalpha (show GRK4 Proteins) activation by PD184161 and metformin, respectively, despite increased IGF-1Rbeta and AMPKalpha (show GRK4 Proteins) levels.

  7. Data indicate that siRNA-mediated knockdown of AMP-activated protein kinase (show PRKAA2 Proteins) alpha (show PAK1 Proteins) subunit (show POLG Proteins) AMPKalpha1 inhibited icaritin-induced autophagy activation, but exacerbated colorectal cancer (CRC (show CALR Proteins)) cell death.

  8. Retinoid-related orphan receptor alpha (RORalpha) reduction occurs in gastric cancer leading to the survival of tumor cells, which is attenuated by AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)), therefore, both RORalpha and AMPK are potential targets for the intervention and therapy in gastric carcinoma.

  9. BCLB (show BCL2L10 Proteins) expression was a starvation stress sensor inducing apoptosis and autophagy simultaneously in HCC (show FAM126A Proteins) cells through the adenosine monophosphate-activated protein kinase AMPK (show GRK4 Proteins)-mTOR (show FRAP1 Proteins) signaling cascade.

  10. findings show that dengue virus ( DENV) infection activates and requires the central metabolic regulator AMPK for its replication and the induction of lipophagy. This is required for the induction of lipophagy, but not basal autophagy, in DENV-infected cells

Zebrafish Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.

Xenopus laevis Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa (show SLC34A1 Proteins) oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.

  2. NDPK-A (show NME1 Proteins) exists in a functional cellular complex with AMPK (show PRKAA2 Proteins) and CFTR (show CFTR Proteins) in airway epithelia, and NDPK-A (show NME1 Proteins) catalytic function is required for the AMPK (show PRKAA2 Proteins)-dependent regulation of CFTR (show CFTR Proteins)

Pig (Porcine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Klotho (show KL Proteins) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 (show RUNX2 Proteins) pathway.

  2. AMPK-mTOR (show FRAP1 Proteins)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  3. Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (show MYLIP Proteins)-1285 and thus activating AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).

  4. L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.

  5. AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.

  6. AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.

  7. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (show MAPK1 Proteins)/TSC2/mTOR (show FRAP1 Proteins) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  8. AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.

  9. AMPK functions to inhibit IGF-I (show IGF1 Proteins)-stimulated PI3K pathway activation through stimulation of IRS-1 (show IRS1 Proteins) serine 794 phosphorylation.

  10. acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation

PRKAA1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with PRKAA1

  • protein kinase, AMP-activated, alpha 3 catalytic subunit (Prkaa3)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (prkaa1)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1)
  • AI194361 protein
  • AI450832 protein
  • AL024255 protein
  • AMPK protein
  • AMPK1 protein
  • AMPKa1 protein
  • AMPKalpha1 protein
  • C130083N04Rik protein
  • cb116 protein
  • im:7154392 protein
  • PRKAA1 protein
  • sb:cb130 protein
  • wu:fa94c10 protein

Protein level used designations for PRKAA1

protein kinase, AMP-activated, alpha 3 catalytic subunit , protein kinase, AMP-activated, alpha 1 catalytic subunit , 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein , 5'-AMP-activated protein kinase catalytic subunit alpha-1 , AMPK-activated protein kinase alpha-1 subunit , 5'-AMP-activated protein kinase alpha 1 catalytic subunit , 5'-AMP-activated protein kinase, catalytic alpha-1 chain , ACACA kinase , AMP -activate kinase alpha 1 subunit , AMP-activated protein kinase, catalytic, alpha-1 , AMPK alpha 1 , AMPK subunit alpha-1 , HMGCR kinase , acetyl-CoA carboxylase kinase , hydroxymethylglutaryl-CoA reductase kinase , tau-protein kinase PRKAA1 , AMPK alpha-1 chain , AMP-activated protein kinase, alpha 1 catalytic subunit , ampka1 , 5'-AMP-activated protein kinase alpha-1 catalytic subunit , AMPKalpha1 , 63 kDa subunit , AMPK 63 kDa subunit

GENE ID SPECIES
108080 Mus musculus
100009710 Equus caballus
100034740 Meleagris gallopavo
100145520 Xenopus (Silurana) tropicalis
100294665 Ovis aries
540404 Bos taurus
5562 Homo sapiens
65248 Rattus norvegicus
105787 Mus musculus
100001198 Danio rerio
495290 Xenopus laevis
427185 Gallus gallus
479351 Canis lupus familiaris
100145903 Sus scrofa
100174304 Pongo abelii
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