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Browse our PRKAA1 Proteins (PRKAA1)

Full name:
Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit Proteins (PRKAA1)
On www.antibodies-online.com are 6 Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Proteins from 4 different suppliers available. Additionally we are shipping PRKAA1 Antibodies (303) and PRKAA1 Kits (17) and many more products for this protein. A total of 335 PRKAA1 products are currently listed.
Synonyms:
AI194361, AI450832, AL024255, AMPK, AMPK1, AMPKa1, AMPKalpha1, C130083N04Rik, cb116, im:7154392, PRKAA1, sb:cb130, wu:fa94c10
list all proteins Gene Name GeneID UniProt
PRKAA1 108080  
PRKAA1 5562 Q13131
Rat PRKAA1 PRKAA1 65248 P54645

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PRKAA1 Proteins (PRKAA1) by Origin

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More Proteins for PRKAA1 Interaction Partners

Mouse (Murine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. the cellular levels of alpha-ketoglutarate (alphaKG), a key metabolite required for TET-mediated DNA demethylation, were profoundly increased and required for active DNA demethylation of the Prdm16 (show PRDM16 Proteins) promoter.

  2. AMPK in adipocytes is vital for maintaining mitochondrial integrity.

  3. Study demonstrated that adenosine monophosphate-activated protein kinase (show GRK4 Proteins) alpha (show PAK1 Proteins) 1 (AMPKalpha1) is imperative for maintaining normal nociception, and mice deficient for AMPKalpha1 exhibit mechanical allodynia.

  4. The data suggest that AMPK is not required for the regulation of the intermediate filament interaction with CPT-I (show CPT1A Proteins) during exercise.

  5. Suggest a novel role for macrophage AMPKalpha1 in arteriogenesis and collateral remodeling and indicate that AMPKalpha1 activation might be beneficial for recovery from occlusive vascular disorders.

  6. Metformin proved chemotherapeutic effect which could be mediated by the activation of adenosine monophosphate protein kinase and related pathways. Combining metformin and doxorubicin, which exhibited different mechanisms of action, produced greater efficacy as anticancer therapeutic regimen

  7. AMPK prevents oxidative stress-induced (show SQSTM1 Proteins) senescence by improving autophagic flux and NAD(+) homeostasis.

  8. p110beta has a role in mediating skeletal muscle metabolic signaling by regulating expression of AMP-activated protein kinase (show PRKAA2 Proteins)

  9. Klotho (show KL Proteins) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 (show RUNX2 Proteins) pathway.

  10. AMPK deficiency results in nuclear CARM1 decrease mediated in part by SKP2, contributing to autophagy dysfunction in the aged heart.

Cow (Bovine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).

  2. The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.

  3. Nitrated oleic acid activates AMPK in endothelial cells.

  4. Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (show SLC12A1 Proteins) involves activation of AMPK.

  5. Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.

  6. the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (show NOS3 Proteins)

Human Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Such effect by miR (show MLXIP Proteins)-429 was again abolished with AMPKalpha1 silence or mutation. Together, we propose that PP2A (show PPP2R4 Proteins)-c silence by miR (show MLXIP Proteins)-429 activates AMPK and protects osteoblastic cells from Dex.

  2. GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.

  3. The AMPK-GFAT1 (show GFPT1 Proteins) signaling axis serves as an important communication point between two nutrient-sensitive signaling pathways and is likely to play a significant role in controlling physiological processes in many other tissues.

  4. Significant association for rs10074991 in PRKAA1 at 5p13.1 for cardia (p=7.36x10(-12)) and non-cardia (p=2.42x10(-23) Gastric adenocarcinoma in Asians was observed.

  5. In conclusion, exenatide significantly improves coronary endothelial function in patients with newly diagnosed type 2 diabetes. The effect may be mediated through activation of AMPK/PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins)/eNOS (show NOS3 Proteins) pathway via a GLP-1R (show GLP1R Proteins)/cAMP-dependent mechanism.

  6. Data suggest that the AMPK-TBC1D4 (show TBC1D4 Proteins) signaling axis is likely mediating the improved muscle insulin (show INS Proteins) sensitivity after contraction/exercise and illuminates an important and physiologically relevant role of AMPK in skeletal muscle.

  7. Thus, APC (show APC Proteins) may be a potential novel therapeutic target for the management of diabetic cardiovascular complications such as diabetic cardiomyopathy.

  8. gomisin N has a protective effect against hepatic steatosis through AMPK activation

  9. Together, the results imply that targeted activation of AMPK by GSK621 inhibits melanoma cell survival and proliferation. MEK (show MAP2K1 Proteins)-ERK (show EPHB2 Proteins) inhibition may further sensitize GSK621's anti-melanoma cell activity in vitro and in vivo.

  10. AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) is a fundamental regulator of energy metabolism, stress resistance, and cellular proteostasis

Zebrafish Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.

Xenopus laevis Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa (show SLC34A1 Proteins) oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.

  2. NDPK-A (show NME1 Proteins) exists in a functional cellular complex with AMPK (show PRKAA2 Proteins) and CFTR (show CFTR Proteins) in airway epithelia, and NDPK-A (show NME1 Proteins) catalytic function is required for the AMPK (show PRKAA2 Proteins)-dependent regulation of CFTR (show CFTR Proteins)

Pig (Porcine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Klotho (show KL Proteins) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 (show RUNX2 Proteins) pathway.

  2. AMPK-mTOR (show FRAP1 Proteins)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  3. Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (show MYLIP Proteins)-1285 and thus activating AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).

  4. L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.

  5. AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.

  6. AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.

  7. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (show MAPK1 Proteins)/TSC2/mTOR (show FRAP1 Proteins) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  8. AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.

  9. AMPK functions to inhibit IGF-I (show IGF1 Proteins)-stimulated PI3K pathway activation through stimulation of IRS-1 (show IRS1 Proteins) serine 794 phosphorylation.

  10. acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation

PRKAA1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with PRKAA1

  • protein kinase, AMP-activated, alpha 3 catalytic subunit (Prkaa3)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (prkaa1)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1)
  • AI194361 protein
  • AI450832 protein
  • AL024255 protein
  • AMPK protein
  • AMPK1 protein
  • AMPKa1 protein
  • AMPKalpha1 protein
  • C130083N04Rik protein
  • cb116 protein
  • im:7154392 protein
  • PRKAA1 protein
  • sb:cb130 protein
  • wu:fa94c10 protein

Protein level used designations for PRKAA1

protein kinase, AMP-activated, alpha 3 catalytic subunit , protein kinase, AMP-activated, alpha 1 catalytic subunit , 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein , 5'-AMP-activated protein kinase catalytic subunit alpha-1 , AMPK-activated protein kinase alpha-1 subunit , 5'-AMP-activated protein kinase alpha 1 catalytic subunit , 5'-AMP-activated protein kinase, catalytic alpha-1 chain , ACACA kinase , AMP -activate kinase alpha 1 subunit , AMP-activated protein kinase, catalytic, alpha-1 , AMPK alpha 1 , AMPK subunit alpha-1 , HMGCR kinase , acetyl-CoA carboxylase kinase , hydroxymethylglutaryl-CoA reductase kinase , tau-protein kinase PRKAA1 , AMPK alpha-1 chain , AMP-activated protein kinase, alpha 1 catalytic subunit , ampka1 , 5'-AMP-activated protein kinase alpha-1 catalytic subunit , AMPKalpha1 , 63 kDa subunit , AMPK 63 kDa subunit

GENE ID SPECIES
108080 Mus musculus
100009710 Equus caballus
100034740 Meleagris gallopavo
100145520 Xenopus (Silurana) tropicalis
100294665 Ovis aries
540404 Bos taurus
5562 Homo sapiens
65248 Rattus norvegicus
105787 Mus musculus
100001198 Danio rerio
495290 Xenopus laevis
427185 Gallus gallus
479351 Canis lupus familiaris
100145903 Sus scrofa
100174304 Pongo abelii
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