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Browse our PRKAA1 Proteins (PRKAA1)

Full name:
Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit Proteins (PRKAA1)
On www.antibodies-online.com are 6 Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Proteins from 4 different suppliers available. Additionally we are shipping PRKAA1 Antibodies (303) and PRKAA1 Kits (21) and many more products for this protein. A total of 339 PRKAA1 products are currently listed.
Synonyms:
AI194361, AI450832, AL024255, AMPK, AMPK1, AMPKa1, AMPKalpha1, C130083N04Rik, cb116, im:7154392, PRKAA1, sb:cb130, wu:fa94c10
list all proteins Gene Name GeneID UniProt
PRKAA1 108080  
PRKAA1 5562 Q13131
Rat PRKAA1 PRKAA1 65248 P54645

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PRKAA1 Proteins (PRKAA1) by Origin

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More Proteins for PRKAA1 Interaction Partners

Mouse (Murine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Ampkalpha1 promotes myocardial AP-1 (show JUN Proteins) activation in a Pkczeta (show PRKCZ Proteins)-dependent manner and thus contributes to cardiac stress signaling.

  2. gomisin N has a protective effect against hepatic steatosis through AMPK activation

  3. Loss of AMPKalpha1 is associated with impaired control of vesicular stomatitis virus infection.

  4. AMPK activation promotes retinal innate defense in endophthalmitis by modulating energy metabolism.

  5. Our findings further revealed that Sesn2 (show SESN2 Proteins)-induced autophagy contributed to restore the impaired insulin (show INS Proteins) signaling through the activation of AMPK signal. Even in the presence of palmitate, Sesn2 (show SESN2 Proteins) up-regulation maintained insulin (show INS Proteins) sensitivity and glucose metabolism via AMPK-dependent autophagic activation.

  6. FGF21 (show FGF21 Proteins) promotes myoblast differentiation and serves as a switch of molecular transformation from anaerobic myofibers to aerobic myofibers via the FGF21 (show FGF21 Proteins)-SIRT1 (show SIRT1 Proteins)-AMPK-PGC1alpha axis.

  7. AMPKalpha1 mediates CHOP (show DDIT3 Proteins) ubiquitination and proteasomal degradation in macrophages by promoting the phosphorylation of CHOP (show DDIT3 Proteins) at serine 30. In a mouse model of plaque stability, deletion of Ampkalpha1 but not Ampkalpha2 (show PRKAA2 Proteins) promoted injury-induced neointimal disruption.

  8. Taken together, these results suggest that exercise influences AMPKalpha2 (show PRKAA2 Proteins) gene methylation in human blood and eminently in the skeletal muscle of mice and therefore might repress AMPKalpha2 (show PRKAA2 Proteins) gene expression.

  9. Angiotensin-II up-regulates the Ampkalpha1 isoform in renal tissue. Ampkalpha1 participates in renal Tak1 (show NR2C2 Proteins) activation and Tak1 (show NR2C2 Proteins)-dependent signaling induced by angiotensin-II.

  10. AMPK activation stimulates oxidant-induced stress granule formation but limits their fusion into larger granules.

Cow (Bovine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).

  2. The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.

  3. Nitrated oleic acid activates AMPK in endothelial cells.

  4. Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (show SLC12A1 Proteins) involves activation of AMPK.

  5. Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.

  6. the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (show NOS3 Proteins)

Human Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Thus, APC (show APC Proteins) may be a potential novel therapeutic target for the management of diabetic cardiovascular complications such as diabetic cardiomyopathy.

  2. gomisin N has a protective effect against hepatic steatosis through AMPK activation

  3. Together, the results imply that targeted activation of AMPK by GSK621 inhibits melanoma cell survival and proliferation. MEK (show MAP2K1 Proteins)-ERK (show EPHB2 Proteins) inhibition may further sensitize GSK621's anti-melanoma cell activity in vitro and in vivo.

  4. AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) is a fundamental regulator of energy metabolism, stress resistance, and cellular proteostasis

  5. FGF21 (show FGF21 Proteins) protects against Ang II (show AGT Proteins)-induced cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 (show TP53 Proteins) activation in an AMPK-dependent manner.

  6. Taken together, these results suggest that exercise influences AMPKalpha2 (show PRKAA2 Proteins) gene methylation in human blood and eminently in the skeletal muscle of mice and therefore might repress AMPKalpha2 (show PRKAA2 Proteins) gene expression.

  7. In summary, the results of the present study demonstrate mechanistic evidences that AMPK-independent programmed necrosis contributes to AICAR's cytotoxicity in prostate cancer cells.

  8. Inhibition of CK2 (show CSNK2A1 Proteins) increased the expression of metabolic regulators, PDK4 (show PDK4 Proteins) and AMPK along with the key cellular energy sensor CREB (show CREB1 Proteins).

  9. AMPK activation stimulates oxidant-induced stress granule formation but limits their fusion into larger granules.

  10. ENO1 (show ENO1 Proteins) is a potent promoter of colorectal cancer genesis and metastasis at least in part though regulating AMPK/mTOR (show FRAP1 Proteins) pathway.

Zebrafish Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.

Xenopus laevis Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa (show SLC34A1 Proteins) oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.

  2. NDPK-A (show NME1 Proteins) exists in a functional cellular complex with AMPK (show PRKAA2 Proteins) and CFTR (show CFTR Proteins) in airway epithelia, and NDPK-A (show NME1 Proteins) catalytic function is required for the AMPK (show PRKAA2 Proteins)-dependent regulation of CFTR (show CFTR Proteins)

Pig (Porcine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK-mTOR (show FRAP1 Proteins)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  2. Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (show MYLIP Proteins)-1285 and thus activating AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).

  3. L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.

  4. AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.

  5. AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.

  6. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (show MAPK1 Proteins)/TSC2/mTOR (show FRAP1 Proteins) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  7. AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.

  8. AMPK functions to inhibit IGF-I (show IGF1 Proteins)-stimulated PI3K pathway activation through stimulation of IRS-1 (show IRS1 Proteins) serine 794 phosphorylation.

  9. acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation

PRKAA1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with PRKAA1

  • protein kinase, AMP-activated, alpha 3 catalytic subunit (Prkaa3)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (prkaa1)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1)
  • AI194361 protein
  • AI450832 protein
  • AL024255 protein
  • AMPK protein
  • AMPK1 protein
  • AMPKa1 protein
  • AMPKalpha1 protein
  • C130083N04Rik protein
  • cb116 protein
  • im:7154392 protein
  • PRKAA1 protein
  • sb:cb130 protein
  • wu:fa94c10 protein

Protein level used designations for PRKAA1

protein kinase, AMP-activated, alpha 3 catalytic subunit , protein kinase, AMP-activated, alpha 1 catalytic subunit , 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein , 5'-AMP-activated protein kinase catalytic subunit alpha-1 , AMPK-activated protein kinase alpha-1 subunit , 5'-AMP-activated protein kinase alpha 1 catalytic subunit , 5'-AMP-activated protein kinase, catalytic alpha-1 chain , ACACA kinase , AMP -activate kinase alpha 1 subunit , AMP-activated protein kinase, catalytic, alpha-1 , AMPK alpha 1 , AMPK subunit alpha-1 , HMGCR kinase , acetyl-CoA carboxylase kinase , hydroxymethylglutaryl-CoA reductase kinase , tau-protein kinase PRKAA1 , AMPK alpha-1 chain , AMP-activated protein kinase, alpha 1 catalytic subunit , ampka1 , 5'-AMP-activated protein kinase alpha-1 catalytic subunit , AMPKalpha1 , 63 kDa subunit , AMPK 63 kDa subunit

GENE ID SPECIES
108080 Mus musculus
100009710 Equus caballus
100034740 Meleagris gallopavo
100145520 Xenopus (Silurana) tropicalis
100294665 Ovis aries
540404 Bos taurus
5562 Homo sapiens
65248 Rattus norvegicus
105787 Mus musculus
100001198 Danio rerio
495290 Xenopus laevis
427185 Gallus gallus
479351 Canis lupus familiaris
100145903 Sus scrofa
100174304 Pongo abelii
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