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These results demonstrate that Poly(ADP-ribosyl)ation of AMPK is a key early signal to efficiently convey extracellular nutrient perturbations with downstream events needed for the cell to optimize autophagic commitment before autophagosome formation.
Data show that oxidative stress and MAP kinase phosphatase 3 (MKP3 (show DUSP6 Proteins)) inhibition play a critical role in procyanidin B2 3,3''-di-O-gallate (B2G2)-induced cell death in prostate cancer (PCa (show FLVCR1 Proteins)) cells through sustained activation of both ERK1/2 and AMPKalpha (show GRK4 Proteins).
vitamin C and edaravone effectively protected macrophages from stress-induced cytotoxicity, accompanied by downregulated SIRT3 (show SIRT3 Proteins) expression and AMPK phosphorylation, and decreased level of autophagy response. Taken together, we conclude that a SIRT3 (show SIRT3 Proteins)/AMPK/autophagy network orchestrates in the protective effect of resveratrol in macrophages.
This review discusses the current understanding of the molecular and physiological regulation of AMPK and its metabolic and physiological functions. In addition discussed are the mechanisms underlying the versatile roles of AMPK in diabetes and cancer. [review]
MAGEA6 (show MAGEA3 Proteins) promotes glioma cell survival possibly via targeting AMPKalpha1.
Depletion of glycolytic intermediates led to a consistent decrease in TXNIP (show TXNIP Proteins) expression in response to 1,25(OH)2D3, an effect that coincided with the activation of AMPK signaling and a reduction in c-MYC (show MYC Proteins) expression.
Here, theauthors identify GIV/Girdin as a novel effector of AMPK, whose phosphorylation at a single site is both necessary and sufficient for strengthening mammalian epithelial tight junctions and preserving cell polarity and barrier function in the face of energetic stress.
PRKAA (show PRKAA2 Proteins) deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L (show DNM1L Proteins).
increasing basal autophagy and AMPK activity by inhibiting GSK3b may be an effective strategy in the setting of hyperglycaemia and dyslipidaemia for restoring endothelial cell health and reducing atherogenesis.
As in patients with PRKAG2 (show PRKAG2 Proteins) cardiomyopathy, iPS (show SLC27A4 Proteins) cell and mouse models are protected from cardiac fibrosis, and we define a crosstalk between AMPK and post-transcriptional regulation of TGFbeta (show TGFB1 Proteins) isoform signaling that has implications in fibrotic forms of cardiomyopathy.
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).
The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.
Nitrated oleic acid activates AMPK in endothelial cells.
Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (show SLC12A1 Proteins) involves activation of AMPK.
Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.
the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (show NOS3 Proteins)
AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.
Klotho (show KL Proteins) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 (show RUNX2 Proteins) pathway.
AMPK-mTOR (show FRAP1 Proteins)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (show MYLIP Proteins)-1285 and thus activating AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).
L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.
AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.
AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (show MAPK1 Proteins)/TSC2/mTOR (show FRAP1 Proteins) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.
AMPK functions to inhibit IGF-I (show IGF1 Proteins)-stimulated PI3K pathway activation through stimulation of IRS-1 (show IRS1 Proteins) serine 794 phosphorylation.
acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation
AMPK regulates T cell survival and function. Demonstrate AMPK-dependent and independent rolesof AICAR (show ATIC Proteins)/Compound C in regulating T cell responses.
AMPK was sufficient to stimulate osteogenesis of MC3T3-E1 cells and inhibit adipogenesis of 3T3-L1 cells through the AMPK-Gfi1 (show ZNF163 Proteins)-OPN (show SPP1 Proteins) axis.
AMPK activation reduces the formation of atheromata-inducing macrophages in ApoE(-/-)-deficient mice by inhibiting expression of Ccr2, thereby preventing the Ccr2-mediated migration of Ly6C(hi) monocytes from the bone marrow.
Thus we concluded that the AMPKalpha (show GRK4 Proteins)-SIRT1 (show SIRT1 Proteins) molecular pathway may be a molecular mechanism of IR in PCOS and may serve as a therapeutic target for the development of potential treatments for improving metabolic and reproductive function in PCOS.
AMPK activation inhibited IL-1beta (show IL1B Proteins)-stimulated CXCL10 (show CXCL10 Proteins) secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4 (show IRAK4 Proteins)) phosphorylation.
Findings indicate that the energy-sensing LKB1 (show STK11 Proteins)-AMPK pathway regulates IGF1 (show IGF1 Proteins) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (show IGF1R Proteins)-PKB (show AKT2 Proteins) pathway.
These data suggest that nutrient availability dictates the mode of division and that LKB1 (show STK11 Proteins)-AMPK mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation.
Myeloid-Restricted AMPKalpha1 Promotes Host Immunity and Protects against IL-12 (show IL12A Proteins)/23p40-Dependent Lung Injury during Hookworm Infection
Data suggest that Il4 (show IL4 Proteins) (usually released from helper T-cells) induces Cox1 in macrophages at post-transcriptional level; activation of Ampk (catalytic subunit Prkaa1) by metformin blocks Il4 (show IL4 Proteins)-dependent induction of Cox1 and blocks macrophage polarization/activation. (Il4 (show IL4 Proteins) = interleukin-4 (show IL4 Proteins); Cox1 = cyclooxygenase 1 (show PTGS1 Proteins); Ampk = AMP-activated protein kinase (show PRKAA2 Proteins))
Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.
NDPK-A (show NME1 Proteins) exists in a functional cellular complex with AMPK (show PRKAA2 Proteins) and CFTR (show CFTR Proteins) in airway epithelia, and NDPK-A (show NME1 Proteins) catalytic function is required for the AMPK (show PRKAA2 Proteins)-dependent regulation of CFTR (show CFTR Proteins)
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
5'-AMP-activated protein kinase catalytic subunit alpha-1
, 5'-AMP-activated protein kinase, catalytic alpha-1 chain
, ACACA kinase
, AMP -activate kinase alpha 1 subunit
, AMP-activated protein kinase, catalytic, alpha-1
, AMPK alpha 1
, AMPK subunit alpha-1
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, tau-protein kinase PRKAA1
, 5'-AMP-activated protein kinase alpha-1 catalytic subunit
, 5'-AMP-activated protein kinase alpha 1 catalytic subunit
, 63 kDa subunit
, AMPK 63 kDa subunit
, AMPK alpha-1 chain
, AMP-activated protein kinase, alpha 1 catalytic subunit
, 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein
, AMPK-activated protein kinase alpha-1 subunit
, protein kinase, AMP-activated, alpha 1 catalytic subunit