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Browse our PRKAA1 Proteins (PRKAA1)

Full name:
Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit Proteins (PRKAA1)
On are 6 Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Proteins from 4 different suppliers available. Additionally we are shipping PRKAA1 Antibodies (261) and PRKAA1 Kits (28) and many more products for this protein. A total of 304 PRKAA1 products are currently listed.
AI194361, AI450832, AL024255, AMPK, AMPK1, AMPKa1, AMPKalpha1, C130083N04Rik, cb116, im:7154392, PRKAA1, sb:cb130, wu:fa94c10
list all proteins Gene Name GeneID UniProt
PRKAA1 108080  
PRKAA1 5562 Q13131
Rat PRKAA1 PRKAA1 65248 P54645

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PRKAA1 Proteins (PRKAA1) by Origin

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More Proteins for PRKAA1 Interaction Partners

Mouse (Murine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. PDE4B (show PDE4B Proteins) phosphorylated by AMPK at Ser304 is important for activation.

  2. Deletion of the AMPK alpha-subunits improves oral but not intraperitoneal glucose tolerance.

  3. The results indicate that AMPK is a negative regulator of Ccr2 (show CCR2 Proteins) expression in RAW264.7 macrophages, and that the mechanism of action of AMPK inhibition of Ccr2 (show CCR2 Proteins) is mediated, in part, through the NF-kappaB (show NFKB1 Proteins) pathway.

  4. Data indicate that an AMP-ctivated kinase (AMPK)/cell-cycle inhibitor p27KIP1 (p27) axis drives activation of autophagy in rapamycin-treated tuberous sclerosis 2 protein (Tsc2)-null cells.

  5. The functional role of AMPKalpha1 in the development of the skeletal system and the pathogenesis of osteoarthritis

  6. AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)), a central metabolic regulator, plays critical roles in lineage specification

  7. BAIBA attenuates insulin (show INS Proteins) resistance, suppresses inflammation and induces fatty acid oxidation via the AMPK-PPARdelta (show PPARD Proteins) pathway in skeletal muscle

  8. These findings suggest that GSH deficiency triggers an AMPK-independent induction of autophagy in germ cells as an adaptive stress response.

  9. Data (including data from studies in knockout mice) suggest, as osteoblasts differentiate, early induction of AMPK in response to IGF-I (show IGF1 Proteins)/IGFBP-2 is followed by suppression of AMPK as required for osteogenesis; activation of AMPK stimulates autophagy.

  10. Data show that the transient receptor potential vanilloid type 1 (TRPV1 (show TRPV1 Proteins)) ligand- induced increase in AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) and nitric oxide synthase type III (eNOS (show NOS3 Proteins)) phosphorylation was markedly lower in TRPV1 (show TRPV1 Proteins)-/- (knockout) than WT aortas.

Cow (Bovine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).

  2. The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.

  3. Nitrated oleic acid activates AMPK in endothelial cells.

  4. Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (show SLC12A1 Proteins) involves activation of AMPK.

  5. Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.

  6. the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (show NOS3 Proteins)

Human Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. our findings suggest that EEKS inhibits the growth of HepG2 cells by inducing AMPK-mediated caspase (show CASP3 Proteins)-dependent apoptosis, suggesting the potential therapeutic application of EEKS in the treatment or prevention of cancers.

  2. Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Proteins) formation upstream of AMP-activated protein kinase (show PRKAA2 Proteins) and protein kinase (show CDK7 Proteins) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 Proteins) pathways and p21 Cip1 (show CDKN1A Proteins) expression.

  3. Data suggest that nitroxoline induces anticancer activity through AMP (show APRT Proteins)-activated kinase (AMPK)/mTOR (show FRAP1 Proteins) serine-threonine kinase (show TLK2 Proteins) (mTOR (show FRAP1 Proteins)) signaling pathway via checkpoint kinase 2 (Chk2 (show CHEK2 Proteins)) activation.

  4. Mutation of Fyn (show FYN Proteins) phosphorylation sites on PIKE (show AGAP2 Proteins)-A, depletion of Fyn (show FYN Proteins), or pharmacological inhibition of Fyn (show FYN Proteins) blunts the association between PIKE (show AGAP2 Proteins)-A and AMPK, resulting in loss of its inhibitory effect on AMPK. regulates AMPK activity in cancers.

  5. Functional characterization revealed an undescribed role for AMPK-dependent phosphorylation of AKAP1 (show AKAP1 Proteins) in mitochondrial respiration.

  6. AMPK phosphorylation of the RHOA (show RHOA Proteins) guanine nucleotide exchange factor (show RASGRF1 Proteins) NET1A (show NET1 Proteins) inhibits extracellular matrix degradation, an early step in cell invasion

  7. Data indicate that long non-coding RNAs (lncRNAs) NBR2 (neighbour of BRCA1 gene 2) interacts with AMP (show APRT Proteins)-activated kinase (AMPK) and promotes AMPK kinase activity during energy stress.

  8. This review focuses on the function of the LKB1 (show STK11 Proteins)/AMPK pathway in the invasion and migration of cancer cells and provides an overview of therapeutic strategies aimed at this pathway in malignant tumors.

  9. Data show that voltage-dependent anion channel 1 (VDAC1 (show VDAC1 Proteins)) knockout cells are resistant to AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) and mechanistic target of rapamycin (mTOR (show FRAP1 Proteins)) modulation by itraconazole, indicating VDAC1 (show VDAC1 Proteins) is the mediator of the activity.

  10. These results suggest that the antitumor effects of paclitaxel in breast cancer are mediated by activation of the AMPK/EF1alpha/FOXO3a (show FOXO3 Proteins) signaling pathway.

Zebrafish Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.

Xenopus laevis Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa (show SLC34A1 Proteins) oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.

  2. NDPK-A (show NME1 Proteins) exists in a functional cellular complex with AMPK (show PRKAA2 Proteins) and CFTR (show CFTR Proteins) in airway epithelia, and NDPK-A (show NME1 Proteins) catalytic function is required for the AMPK (show PRKAA2 Proteins)-dependent regulation of CFTR (show CFTR Proteins)

Pig (Porcine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (show MYLIP Proteins)-1285 and thus activating AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).

  2. L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.

  3. AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.

  4. AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.

  5. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (show MAPK1 Proteins)/TSC2/mTOR (show FRAP1 Proteins) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  6. AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.

  7. AMPK functions to inhibit IGF-I (show IGF1 Proteins)-stimulated PI3K pathway activation through stimulation of IRS-1 (show IRS1 Proteins) serine 794 phosphorylation.

  8. acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation

PRKAA1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with PRKAA1

  • protein kinase, AMP-activated, alpha 3 catalytic subunit (Prkaa3)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (prkaa1)
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1)
  • AI194361 protein
  • AI450832 protein
  • AL024255 protein
  • AMPK protein
  • AMPK1 protein
  • AMPKa1 protein
  • AMPKalpha1 protein
  • C130083N04Rik protein
  • cb116 protein
  • im:7154392 protein
  • PRKAA1 protein
  • sb:cb130 protein
  • wu:fa94c10 protein

Protein level used designations for PRKAA1

protein kinase, AMP-activated, alpha 3 catalytic subunit , protein kinase, AMP-activated, alpha 1 catalytic subunit , 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein , 5'-AMP-activated protein kinase catalytic subunit alpha-1 , AMPK-activated protein kinase alpha-1 subunit , 5'-AMP-activated protein kinase alpha 1 catalytic subunit , 5'-AMP-activated protein kinase, catalytic alpha-1 chain , ACACA kinase , AMP -activate kinase alpha 1 subunit , AMP-activated protein kinase, catalytic, alpha-1 , AMPK alpha 1 , AMPK subunit alpha-1 , HMGCR kinase , acetyl-CoA carboxylase kinase , hydroxymethylglutaryl-CoA reductase kinase , tau-protein kinase PRKAA1 , AMPK alpha-1 chain , AMP-activated protein kinase, alpha 1 catalytic subunit , ampka1 , 5'-AMP-activated protein kinase alpha-1 catalytic subunit , AMPKalpha1 , 63 kDa subunit , AMPK 63 kDa subunit

108080 Mus musculus
100009710 Equus caballus
100034740 Meleagris gallopavo
100145520 Xenopus (Silurana) tropicalis
100294665 Ovis aries
540404 Bos taurus
5562 Homo sapiens
65248 Rattus norvegicus
105787 Mus musculus
100001198 Danio rerio
495290 Xenopus laevis
427185 Gallus gallus
479351 Canis lupus familiaris
100145903 Sus scrofa
100174304 Pongo abelii
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