Histone Deacetylase 1 (HDAC1) (Internal Region) antibody

Details for Product No. ABIN1043884
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Antigen
Synonyms
HD1, RPD3, Hdac1, Gm1824, EG15181, Hdac1-ps, ENSMUSG00000061062, Rpd3, GB14706, hdac1, rpd3, yaf1, gon-10, hdac1-b, rpd3l1, ARABIDOPSIS HISTONE DEACETYLASE 1, ARABIDOPSIS HISTONE DEACETYLASE 19, ATHD1 ... show more
HD1, RPD3, Hdac1, Gm1824, EG15181, Hdac1-ps, ENSMUSG00000061062, Rpd3, GB14706, hdac1, rpd3, yaf1, gon-10, hdac1-b, rpd3l1, ARABIDOPSIS HISTONE DEACETYLASE 1, ARABIDOPSIS HISTONE DEACETYLASE 19, ATHD1, ATHDA19, ATRPD3A, F20D10.250, F20D10_250, HDA1, HDA19, HISTONE DEACETYLASE, HISTONE DEACETYLASE 19, HISTONE DEACETYLASE19, RPD3A, histone deacetylase 1, CG7471, DHDAC1, DRpd3, DmHDAC1, Dmel\\CG7471, E(var)3-64BC, HDAC, HDAC-1, HDAC1, Rpd3/HDAC, Su(var)3-26, Su(var)326, Su(var)328, dHDAC-1, dHDAC1, dRPD3, dRpd3, dmHDA401, drpd3, l(3)04556, l(3)64Cc, rpd[3], GON-10, RPD3L1, MommeD5, chunp6919, hdac-1, mp:zf637-2-001987, wu:fb19h11, wu:fi06f03, zgc:101582, zgc:65818, hdac1b show less
Epitope
Internal Region
(66), (34), (33), (18), (16), (9), (8), (8), (8), (7), (7), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(300), (150), (145), (43), (41), (37), (16), (12), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(255), (54), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1)
Application
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
(250), (121), (77), (73), (67), (40), (34), (24), (17), (12), (12), (3), (3), (3), (3), (2), (1)
Pubmed 1 reference available
Quantity 25 μL
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Catalog No. ABIN1043884
126.50 $
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Immunogen Anti-HDAC-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 466-482 of Human HDAC-1.
Immunogen Type: Peptide
Isotype IgG
Specificity Anti-HDAC-1 antibody is directed against human HDAC-1 protein. HDAC-1 antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from human, mouse, rat and chimpanzee sources based on 100% homology for the immunogen sequence. Cross reactivity may occur with HDAC-1 from bovine (82% homology) and chicken (80% homology) sources. Cross reactivity with HDAC-1 homologues from other sources has not been determined.
Characteristics HDAC-1 antibody recognizes HDAC1 (also known as HD1, histone deacetylase 1, RPD3, RPD3L1) which belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Sterility Sterile filtered
Alternative Name HDAC-1
Background HDAC-1 antibody recognizes HDAC1 (also known as HD1, histone deacetylase 1, RPD3, RPD3L1) which belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Synonyms: GON 10 antibody, HD 1 antibody, hdac1: histone deacetylase 1 antibody, Histone deacetylase 1 (HD1) antibody, Histone deacetylase 1 antibody, RPD3 (reduced potassium dependency yeast homolog) like 1 antibody
Gene ID 3065, 13128860
UniProt Q13547
Research Area DNA/RNA, Transcription Factors
Application Notes Anti-HDAC-1 Antibody has been tested for use in ELISA, immunohistochemistry and western blot. Specific conditions for reactivity should be optimized by the end user. Specific nuclear staining is observed by IHC. Expect bands at 65 kDa in size corresponding to HDAC-1 by western blotting in the appropriate cell lysate or extract.
Comment

Gene Name: HDAC1

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store vial at 4° C prior to restoration.   For extended storage aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing.  Centrifuge product if not completely clear after standing at room temperature.  This product is stable for several weeks at 4° C as an undiluted liquid.  Dilute only prior to immediate use.  Expiration date is one (1) year from date of opening.
Expiry Date 12 months
Supplier Images
anti-Histone Deacetylase 1 (HDAC1) (Internal Region) antibody Immunohistochemistry of Rabbit Anti-HDAC-1 Antibody. Tissue: human prostate cancer tissue. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: HDAC-1 antibody at 1:500 for 1 h at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: HDAC-1 is nuclear. Staining: HDAC-1 precipitated purple with blue counterstain.
anti-Histone Deacetylase 1 (HDAC1) (Internal Region) antibody (2) anti-Histone Deacetylase 1 (HDAC1) (Internal Region) antibody (Image 2)
Product cited in: Unoki, Nishidate, Nakamura: "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain." in: Oncogene, Vol. 23, Issue 46, pp. 7601-10, 2004 (PubMed).

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