Heterogeneous Nuclear Ribonucleoprotein L (HNRNPL) antibody

Details for Product No. ABIN108588
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Antigen
Synonyms hnrnpl, hnrpl, wu:fb53f10, wu:fp61c04, zgc:66175, HNRNPL, HNRPL, hnRNP-L, C79783, D830027H13Rik, Hnrpl, zgc:55429, hnrnp-L
Reactivity
Mouse (Murine), Rat (Rattus), Human, Newt
(60), (32), (18), (15), (12), (12), (6), (4), (2), (2), (1)
Host
Mouse
(47), (14)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
(52), (29), (26), (25), (15), (14), (10), (10), (5), (2), (2), (1), (1)
Pubmed 10 references available
Quantity 0.1 mL
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Catalog No. ABIN108588
576.05 $
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Immunogen Human hnRNP proteins (from HeLa cells) purified by affinity chromatography on ssDNA agarose
Clone 4D11
Isotype IgG1
Characteristics Myeloma fusion partners:
SP2/0
Detects a band of approximately 64 kDa (predicted molecular weight: 64 kDa).
Purification Protein A
Alternative Name hnRNP L
Background Synonyms:
D830027H13Rik antibody,FLJ35509 antibody,Heterogeneous nuclear ribonucleoprotein L antibody,hnRNPLantibody,hnRPL antibody,P/OKcl.14 antibody
UniProt Q8R081
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try, IHC-P: Use a concentration of 1 µg/mL. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. WB: 1/2000. Flow Cyt: Use 1µg for 106 cells.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, 0.1 % sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Storage 4 °C
Supplier Images
anti-Heterogeneous Nuclear Ribonucleoprotein L (HNRNPL) antibody Western blot for anti-hnRNP-L on HeLa cell extracts
anti-Heterogeneous Nuclear Ribonucleoprotein L (HNRNPL) antibody (2) anti-Heterogeneous Nuclear Ribonucleoprotein L (HNRNPL) antibody (Image 2)
Product cited in: Piñol-Roma, Swanson, Gall et al.: "A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts." in: The Journal of cell biology, Vol. 109, Issue 6 Pt 1, pp. 2575-87, 1990 (PubMed).

Rothrock, House, Lynch: "HnRNP L represses exon splicing via a regulated exonic splicing silencer." in: The EMBO journal, Vol. 24, Issue 15, pp. 2792-802, 2005 (PubMed).

Melton, Jackson, Wang et al.: "Combinatorial control of signal-induced exon repression by hnRNP L and PSF." in: Molecular and cellular biology, Vol. 27, Issue 19, pp. 6972-84, 2007 (PubMed).

Venables, Koh, Froehlich et al.: "Multiple and specific mRNA processing targets for the major human hnRNP proteins." in: Molecular and cellular biology, Vol. 28, Issue 19, pp. 6033-43, 2008 (PubMed).

Jia, Liu, Tao et al.: "Control of the papillomavirus early-to-late switch by differentially expressed SRp20." in: Journal of virology, Vol. 83, Issue 1, pp. 167-80, 2008 (PubMed).

Wang, Cambi: "Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11194-204, 2009 (PubMed).

Niu, Terasaki, Komatsu et al.: "Identification of peptides applicable as vaccines for HLA-A26-positive cancer patients." in: Cancer science, Vol. 100, Issue 11, pp. 2167-74, 2009 (PubMed).

Heyd, Lynch: "Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing." in: Molecular cell, Vol. 40, Issue 1, pp. 126-37, 2010 (PubMed).

Motta-Mena, Smith, Mallory et al.: "A disease-associated polymorphism alters splicing of the human CD45 phosphatase gene by disrupting combinatorial repression by heterogeneous nuclear ribonucleoproteins (hnRNPs)." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 20043-53, 2011 (PubMed).

Peddigari, Li, Rabe et al.: "hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition." in: Nucleic acids research, Vol. 41, Issue 1, pp. 575-85, 2012 (PubMed).

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