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Details for Product No. ABIN108588

Heterogeneous Nuclear Ribonucleoprotein L (HNRNPL) antibody

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Antigen
Synonyms HNRPL, hnRNP-L, zgc:55429, hnrpl, Hnrpl, C79783, D830027H13Rik, hnrnp-L, hnrnpl, wu:fb53f10, wu:fp61c04, zgc:66175, HNRNPL
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Human, Newt
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC)
Pubmed 10 references available
Catalog no. ABIN108588
Quantity 0.1 mL
Price
576.05 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 6 Business Days
Immunogen Human hnRNP proteins (from HeLa cells) purified by affinity chromatography on ssDNA agarose
Myeloma Fusion Partners: SP2/0
Clone 4D11
Isotype IgG1
Specificity Human hnRNP-L. Detects a band of approximately 65 kDa. It cross reacts with mouse & newt
Characteristics Mouse Anti-hnRNP L [4D11]
Purification Protein A
Alternative Name hnRNP L
Gene ID 80846
OMIM 603083
UniProt Q8R081
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try IHC-P: Use a concentration of 1 µg/mL. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. WB: 1/2000. Detects a band of approximately 64 kDa (predicted molecular weight: 64 kDa). Flow Cyt: Use 1µg for 106 cells.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Purified antibody (from supernatant) containing PBS 0.1% sodium azide
Preservative Sodium azide
Storage 4 °C
Product cited in: Piñol-Roma, Swanson, Gall et al.: "A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts." in: The Journal of cell biology, Vol. 109, Issue 6 Pt 1, pp. 2575-87, 1990 (PubMed).

Rothrock, House, Lynch: "HnRNP L represses exon splicing via a regulated exonic splicing silencer." in: The EMBO journal, Vol. 24, Issue 15, pp. 2792-802, 2005 (PubMed).

Melton, Jackson, Wang et al.: "Combinatorial control of signal-induced exon repression by hnRNP L and PSF." in: Molecular and cellular biology, Vol. 27, Issue 19, pp. 6972-84, 2007 (PubMed).

Venables, Koh, Froehlich et al.: "Multiple and specific mRNA processing targets for the major human hnRNP proteins." in: Molecular and cellular biology, Vol. 28, Issue 19, pp. 6033-43, 2008 (PubMed).

Jia, Liu, Tao et al.: "Control of the papillomavirus early-to-late switch by differentially expressed SRp20." in: Journal of virology, Vol. 83, Issue 1, pp. 167-80, 2008 (PubMed).

Wang, Cambi: "Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11194-204, 2009 (PubMed).

Niu, Terasaki, Komatsu et al.: "Identification of peptides applicable as vaccines for HLA-A26-positive cancer patients." in: Cancer science, Vol. 100, Issue 11, pp. 2167-74, 2009 (PubMed).

Heyd, Lynch: "Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing." in: Molecular cell, Vol. 40, Issue 1, pp. 126-37, 2010 (PubMed).

Motta-Mena, Smith, Mallory et al.: "A disease-associated polymorphism alters splicing of the human CD45 phosphatase gene by disrupting combinatorial repression by heterogeneous nuclear ribonucleoproteins (hnRNPs)." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 20043-53, 2011 (PubMed).

Peddigari, Li, Rabe et al.: "hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition." in: Nucleic acids research, Vol. 41, Issue 1, pp. 575-85, 2012 (PubMed).

Alternatives for antigen "Heterogeneous Nuclear Ribonucleoprotein L (HNRNPL)", type "Antibodies"
Hosts (39), (10)
Reactivities (45), (28), (16), (15), (12), (12), (3), (3), (2), (2), (1)
Applications (40), (21), (20), (18), (10), (10), (8), (6), (4), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
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