CD6 (CD6) (AA 472-668) antibody

Details for Product No. ABIN1098118
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Antigen
Synonyms TP120, OX52
Epitope
AA 472-668
(10), (9), (3), (2), (1), (1), (1), (1)
Reactivity
Human
(102), (27), (25), (6), (5)
Host
Mouse
(96), (41), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(17), (14), (12), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(102), (53), (33), (22), (22), (20), (11), (10), (10), (5), (4), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN1098118
396.00 $
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Immunogen Purified recombinant fragment of human CD6 (AA 472-668) expressed in E. coli.
Clone 6B9
Isotype IgG1
Purification Purified
Alternative Name CD6
Background Synonyms:
TP120, FLJ44171
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Molecular Weight 71.8 kDa
Gene ID 923
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Buffer PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-CD6 (CD6) (AA 472-668) antibody Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng)
anti-CD6 (CD6) (AA 472-668) antibody (2) Figure 3: Immunohistochemical analysis of paraffin-embedded stomach cancer tissues using CD6 mouse mAb with DAB staining.
anti-CD6 (CD6) (AA 472-668) antibody (3) Figure 1: Western blot analysis using CD6 mAb against human CD6 recombinant protein. (Expected MW is 46.9 kDa)
anti-CD6 (CD6) (AA 472-668) antibody (4) Figure 2: Western blot analysis using CD6 mAb against HEK293 (1) and CD6 (AA: 472-668) -hIgGFc transfected HEK293 (2) cell lysate.
Product cited in: Sarrias, Farnós, Mota et al.: "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 28, pp. 11724-9, 2007 (PubMed).

Alonso, Buors, Le Dantec et al.: "Aberrant expression of CD6 on B-cell subsets from patients with Sjögren's syndrome." in: Journal of autoimmunity, Vol. 35, Issue 4, pp. 336-41, 2010 (PubMed).

Background publications De Jager, Jia, Wang et al.: "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci." in: Nature genetics, Vol. 41, Issue 7, pp. 776-82, 2009 (PubMed).

Kofler, Severson, Mousissian et al.: "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 6, pp. 3286-91, 2011 (PubMed).

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