human Splunc2 (AA 16-250) antibody

Antigen: human Splunc2

Binding Site: AA 16-250

Clonality: Monoclonal (4C7D7)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Catalog no.: ABIN1098132

Additional Information

Immunogen: Purified recombinant fragment of human Splunc2 (AA: 16-250) expressed in E. Coli.

Isotype: IgG1

Clone: 4C7D7

Description: Synonyms: BPIFA2, PSP, SPLUNC2, C20orf70, bA49G10.1.
SPLUNC2 is one member of PLUNC family, the gene undergoes alternative splicing using two 5' non-coding exons, suggesting that the gene is regulated by alternative promoters.multiple SPLUNC2 isoforms are found in the oral cavity and suggest that these proteins may be differentially regulated in distinct tissues where they may function in the innate immune response. Mucin plugs, mucous and intermediate cells of mucoepidermoid carcinomas were positive for LPLUNC1 and SPLUNC2, but areas composed of epidermoid and clear cells were negative for all PLUNCs. Papillary cystadenocarcinoma was positive for all PLUNCs.

Molecular Weight: 27kDa

Application Details

Application Notes: ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400

Buffer: PBS + 0.5% protein stabilizer

Preservative: 0.05% sodium azide

Storage: Store at 4°C, for long term storage, store at -20°C

Restrictions: For Research Use only

Publications

Product: Vargas, Speight, Bingle et al.: "Expression of PLUNC family members in benign and malignant salivary gland tumours." in: Oral diseases, Vol. 14, Issue 7, pp. 613-9, 2008 (PubMed).

Bingle, Barnes, Lunn et al.: "Characterisation and expression of SPLUNC2, the human orthologue of rodent parotid secretory protein." in: Histochemistry and cell biology, Vol. 132, Issue 3, pp. 339-49, 2009 (PubMed).