beta Amyloid antibody (N-Term)

Catalog No. ABIN1105360

This Mouse Monoclonal antibody specifically detects beta Amyloid in WB and IHC (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for beta Amyloid antibody (N-Term) (ABIN1105360)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Amyloid antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2C8

Product Details anti-beta Amyloid Antibody

Binding Specificity: AA 1-16, N-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, weakly with mouse brain

Purification: Protein-A Sepharose

Immunogen: Synthetic amyloid beta peptide corresponding to amino acids 1-16 of human amyloid beta

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2, without preservatives

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Alternative Name: Amyloid beta

Background: Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques is a 39-42 amino acid peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial early-onset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: ß-secretase and gamma-secretase. Recent study suggested that a transmembrane aspartic protease, termed beta-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase. This antibody recognizes N-terminal of Aß 40 and Aß 42 specifically.Synonyms: Amyloid beta peptide

Pathways: Inflammasome