IKZF4 antibody (N-Term)

Catalog No. ABIN1109609

The Rabbit Polyclonal anti-IKZF4 antibody has been validated for WB. It is suitable to detect IKZF4 in samples from Human, Mouse, Rat and Dog.

Quick Overview for IKZF4 antibody (N-Term) (ABIN1109609)

Target: IKZF4 (IKAROS Family Zinc Finger 4 (Eos) (IKZF4))

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IKZF4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IKZF4 Antibody

Binding Specificity: N-Term

Sequence: NSIKVEMYSD EESSRLLGPD ERLLEKDDSV IVEDSLSEPL GYCDGSGPEP

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat, Dog

Purification: Purified using Protein A affinity column

Immunogen: The immunogen for anti-ZNFN1A4 antibody: synthetic peptide directed towards the N terminal of human ZNFN1A4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 100 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for IKZF4

Target: IKZF4 (IKAROS Family Zinc Finger 4 (Eos) (IKZF4))

Alternative Name: ZNFN1A4 / IKZF4 / EOS

Background: IKZF4 also called ZNFN1A4 is a DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence and acts as transcriptional repressor. It interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2 and may be involved in the development of central and peripheral nervous systems. Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.Synonyms: Ikaros family zinc finger protein 4, KIAA1782, Zinc finger protein Eos

Molecular Weight: 64 kDa (585 aa)

Gene ID: 64375

NCBI Accession: NP_071910