The antibody for the detection of Wingless-Type MMTV Integration Site Family Member 2 (WNT2) (N-Term) has now been successfully validated for immunohistochemistry. A signal was observed in human glioma tissue, while no signal could be detected in human brain tissue.The WNT gene family consists of structurally related genes encoding secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. » Read more
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The antibody for the detection of Runt-Related Transcription Factor 3 (RUNX3) has now been successfully validated for immunofluorescence. A strong signal was observed in the human cellline A431 (epidermoid carcinoma), while no signal could be detected in the isotype staining and staining of HEK293 cells.A complex formed of a heterodimer of Runt-Related Transcription Factor 3 (RUNX3) and a beta subunit binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters. That can either activate or suppress transcription. RUNX3 can also interact with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. » Read more