The antibody for the detection of Cadherin 5 (CDH5) has now been successfully validated for immunofluorescence. A clear signal of the calcium-depending adhesion molecule was achieved in murine liver tissue while murine brain tissue (known to be negative for cadherin 5) remained unstained.Cadherin 5 (also called CD144) is a vascular endothelial cadherin. This type of cadherins appears at the contact site of endothelial cells. They are functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, and additional they fundction also as a desmosome. » Read more
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- Their purpose is to function as a barrier, protecting the body from mechanical damage, invading micro organisms and the loss of body fluids.
- Detection of epithelial cells has a central role in research on cancer diseases.
- A range of antibodies has been established for detection of individual epithelial cells.
- Some standard markers are: anti-epithelial membrane antigen (EMA) antibody and pan-cytokeratin antibody
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