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Independent Validation
Independent Validation

The antibody for the detection of Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1) has now been successfully validated for immunohistochemistry. A signal was observed in human kidney tubules, while no signal could be detected in human colon stromal tissue.

Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1) participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. It plays a role both in canonical and non-canonical Wnt signaling, and it has a role in the signal transduction pathways mediated by multiple Wnt genes. It is required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).  » 

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We offer a variety of peer-validated polyclonal and monoclonal antibodies mainly focused on human targets, a couple of secondary antibodies mainly capable in Western Blot and ELISA, and a few proteins like sepharose coupled Protein A and G.

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