Traditionally, production of recombinant proteins has been split between two equally unpalatable options. Eukaryotic expression systems offer a slow, labor-intensive process that renders an expensive end-product. Production in E. coli is fast, simple and inexpensive, but formation of inclusion bodies (aggregates of misfolded or improperly translated proteins) have limited both the yield of protein produced and the complexity of protein products that can be produced by the simple prokaryote.
By leveraging extensive knowledge of the E. coli genome, AbSci has perfected a technique that allows for high-yield production of complex proteins in genetically engineered E. coli with virtually no development of inclusion bodies. The technique allows for rapid, inexpensive development of highly complex recombinant proteins. This new technology paves the way for rapid, high-yield, inexpensive production of complex products like antibodies in a prokaryotic system.
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