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Independent Validation
Independent Validation

The antibody for the detection of Wingless-Type MMTV Integration Site Family Member 2 (WNT2) (N-Term) has now been successfully validated for immunohistochemistry. A signal was observed in human glioma tissue, while no signal could be detected in human brain tissue.

The WNT gene family consists of structurally related genes encoding secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.  » 

(…) Since last summer Andreas Kessel and Tim Hiddemann from antibodies-online.com support the initiators of Science Exchange. The former spin-off headquartered in Aachen currently delivers more than one million antibodies to laboratories all over the world. It is the task of this cooperation to make antibodies to provide qualitative comparability for antibodies, which are used in biomedical sciences. Scientists and manufacturers can suggest antibodies for validation, which will then be tested in independent laboratories of one of the 1,400 research facilities that build the Science Exchange network. After successful testing the “Independently Validated" label with individual identification number will be granted. This label is intended to be not only a tool for easy validation of scientific studies. Furthermore, with purchase of tested products researchers obtain certainty that antibodies work as it is described in test protocols – and that they are the most suitable choice for the respective question. (...) Source: http://www.spiegel.de/wissenschaft/medizin/qualitaet-der-forschung-rettet-die-wissenschaft-a-959629.html

Independent Validation
Independent Validation

The antibody for the detection of Runt-Related Transcription Factor 3 (RUNX3) has now been successfully validated for immunofluorescence. A strong signal was observed in the human cellline A431 (epidermoid carcinoma), while no signal could be detected in the isotype staining and staining of HEK293 cells.

A complex formed of a heterodimer of Runt-Related Transcription Factor 3 (RUNX3) and a beta subunit binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters. That can either activate or suppress transcription. RUNX3 can also interact with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer.  »