beta Endorphin antibody

Catalog No. ABIN111317

The Mouse Monoclonal anti-beta Endorphin antibody is suitable to detect beta Endorphin in samples from Human. It has been validated for IHC (fro), IHC (p) and IF.

Quick Overview for beta Endorphin antibody (ABIN111317)

Target: beta Endorphin (beta-EP) (Endorphin beta (beta-EP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Endorphin antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: B31-15

Product Details anti-beta Endorphin Antibody

Purification: Affinity chromatography on Protein A

Immunogen: Human beta endorphin (full length native protein).

Isotype: IgG1

Application Details

Application Notes: Immunofluorescence. Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections: Microwave pretreatment is recommended. Recommended positive Control: Human pituitary gland.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for beta Endorphin

Target: beta Endorphin (beta-EP) (Endorphin beta (beta-EP))

Alternative Name: beta Endorphin

Background: Beta-Endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system. Beta-Endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor pro-opiomelanocortin (POMC). Beta-Endorphin is found in neurons of the hypothalamus as well as the pituitary gland. It is an agonist of the opioid receptors, with evidence suggesting that it serves as the endogenous ligand of the μ-opioid receptor, the same receptor to which the chemicals extracted from opium, such as morphine and codeine, have their analgesic and addictive effects. Beta-Endorphin occurs in cells in the anterior pituitary. Beta-Endorphin may be detected in tumors of the pituitary, gastroinestinal and bronchial carcinoids. Absorption with 10-100 μg beta-Endorphin per ml diluted antiserum inactivates the antiserum, while Beta-lipotropin, met-enkephalin and leu-enkephalin do not.Synonyms: Endorfin-beta, Endorphin-beta

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity