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Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 (LRPAP1) antibody

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Synonyms wu:fi20f07, wu:fi22c06, LRPAP1, DKFZp459I2430, A2MRAP, A2RAP, HBP44, MRAP, RAP, AA617339, AI790446, AU042172, C77774
(82), (25), (16), (3), (2), (1), (1), (1)
(68), (22), (10)
Clonality (Clone)
Monoclonal ()
(12), (9), (2), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(71), (46), (26), (21), (7), (6), (5), (4), (4), (2), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Human RAP.
Clone 7F1
Isotype IgG1
Specificity This antibody BM5054 (7F1) reacts with the 39 kDa RAP protein, which is cosynthesized with Human LRP/alpha2MR (low density lipoprotein receptor-related protein/alpha2-Macro-Globulin Receptor). It inhibits the binding of ligands, e.g. tPA, uPA, VLDL, liproprotein lipase, and alpha2-Macroglobulin-proteinase complexes to LRP/A2MR.
Purification Affinity Chromatography on Protein A .
Alternative Name LRPAP1 / A2MRAP (LRPAP1 Antibody Abstract)
Background Low density lipoprotein receptor-related protein-associated protein 1 (RAP) interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains. Binds LRP1B, binding is followed by internalization and degradation. In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.Synonyms: Alpha-2-MRAP, Alpha-2-macroglobulin receptor-associated protein, Low density lipoprotein receptor-related protein-associated protein 1, RAP
Gene ID 4043
NCBI Accession NP_002328
UniProt P30533
Application Notes Immunoblotting. Immunofluorescence. Immunohistochemistry: 1/20. Ligand-binding assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore in 1 mL distilled water.
Buffer PBS buffer, pH 7.4 containing 0.5 % BSA as stabilizer.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Background publications Kounnas, Argraves, Strickland: "The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330." in: The Journal of biological chemistry, Vol. 267, Issue 29, pp. 21162-6, 1992 (PubMed).

Catalog No. ABIN112189
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