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Details for Product No. ABIN112189

Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 (LRPAP1) antibody

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Antigen
Synonyms A2MRAP, A2RAP, HBP44, MRAP, RAP, C77774, AA617339, AI790446, AU042172, wu:fi20f07, wu:fi22c06, LRPAP1, DKFZp459I2430
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN112189
Quantity 50 µg
Price
445.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Human RAP.
Clone 7F1
Isotype IgG1
Specificity This antibody BM5054 (7F1) reacts with the 39 kDa RAP protein, which is cosynthesized with Human LRP/alpha2MR (low density lipoprotein receptor-related protein/alpha2-Macro- Globulin Receptor). It inhibits the binding of ligands, e.g. tPA, uPA, VLDL, liproprotein lipase, and alpha2-Macroglobulin-proteinase complexes to LRP/A2MR.
Purification Affinity Chromatography on Protein A .
Alternative Name LRPAP1 / A2MRAP
Background Low density lipoprotein receptor-related protein-associated protein 1 (RAP) interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains. Binds LRP1B, binding is followed by internalization and degradation. In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
Alternate names: Alpha-2-MRAP, Alpha-2-macroglobulin receptor-associated protein, Low density lipoprotein receptor-related protein-associated protein 1, RAP
Gene ID 4043
NCBI Accession NP_002328.1
UniProt P30533
Application Notes Immunoblotting. Immunofluorescence. Immunohistochemistry: 1/20. Ligand-binding assays. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore in 1 mL distilled water.
Buffer PBS buffer, pH 7.4 containing 0.5% BSA as stabilizer.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Expiry Date 12 months
Kounnas, Argraves, Strickland: "The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330." in: The Journal of biological chemistry, Vol. 267, Issue 29, pp. 21162-6, 1992 (PubMed).

Alternatives for antigen "Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 (LRPAP1)", type "Antibodies"
Hosts (33), (14), (5)
Reactivities (45), (17), (16), (13), (3), (1), (1), (1)
Applications (38), (16), (15), (10), (8), (4), (2), (2), (2), (1)
Conjugates (6), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (2), (1)
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