Vasopressin antibody

Catalog No. ABIN112917

This anti-Vasopressin antibody is a Rabbit Polyclonal antibody detecting Vasopressin in IF, IHC (p) and IHC (fro). Suitable for Human.

Quick Overview for Vasopressin antibody (ABIN112917)

Target: Vasopressin (AVP) (Arginine Vasopressin (AVP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Vasopressin antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Vasopressin Antibody

Specificity: This antibody is specific for Arginine Vasopressin, also known as antidiuretic hormone. The sequence of ARG-Vasopressin is 100 % identical in a vast number of species such as Human, Mouse, Rat, Cat, Dog, Bovine, Sheep, Guinea Pig, so a broad species. crossreactivity is to be expected.

Purification: Affinity Chromatography on Protein G

Immunogen: Synthetic Arginine Vasopressin conjugated to Bovine thyroglobulin

Application Details

Application Notes: Immunohistochemistry on Frozen and Paraffin Embedded Tissues. Immunofluorescence. Histology Positive Control Tissue: Hypothalamus and posterior lobe of the pituitary gland.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 5.0 mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Vasopressin

Target: Vasopressin (AVP) (Arginine Vasopressin (AVP))

Alternative Name: Vasopressin-Neurophysin 2-Copeptin

Background: Vasopressin, also known as arginine vasopressin (AVP), or antidiuretic hormone (ADH), is a posterior pituitary hormone that is synthesised in the hypothalamus. Vasopressin is synthesised as a precursor protein that consists of arginine vasopressin and two associated proteins, neurophysin 2 and the glycopeptide copeptin. Vasopressin, together with its carrier protein neurophysin II, is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. Vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney and also causes vasoconstriction of the peripheral vessels. Vasopressin can also contract smooth muscle during parturition and lactation. It also plays a role in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in the vasopressin precursor cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI), which is characterised by persistant thirst, polydipsia and polyuria. Arginine vasopressin is a nine amino acid peptide secreted from the posterior pituitary in response to reductions in plasma volume and increases is plasma osmolarity. Its release triggers water reabsorption due to the insertion of aquaporins in the membranes of kidney tubules which transport solute-free water through tubular cells and back into the blood.Synonyms: ARVP, AVP, Antidiuretic Hormone, Arginine vasopressin

Gene ID: 551

NCBI Accession: NP_000481

UniProt: P01185

Pathways: cAMP Metabolic Process