Osteoprotegerin antibody

Catalog No. ABIN114706

This Mouse Monoclonal antibody specifically detects Osteoprotegerin in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for Osteoprotegerin antibody (ABIN114706)

Target: Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Osteoprotegerin antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: OPG-01

Product Details anti-Osteoprotegerin Antibody

Specificity: The antibody recognizes human Osteoprotegerin. Other species not tested.

Purification: Affinity chromatography on protein G

Immunogen: Recombinant human Osteoprotegerin (OPG Fc Chimera) produced in E. coli.

Isotype: IgG1

Application Details

Application Notes: ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 0.1 mL of deionized water. Let the pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.

Concentration: 1.0 mg/mL

Buffer: 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2

Handling Advice: Avoid repeated freezing and thawing. Do Not Freeze working dilutions.

Storage: -20 °C

Storage Comment: Stock solution or aliquots thereof can be kept frozen at -20 °C.

Target Details for Osteoprotegerin

Target: Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))

Alternative Name: Osteoprotegerin / TNFRSF11B

Target Type: Chemical

Background: Osteoprotegerin (OPG) or osteoclastogenesis inhibitory factor (OCIF) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 amino acid residues, it has a molecular weight of 60 kDa as a monomer and 120 kDa as a disulfide-linked dimer and is produced in different tissues, e.g. bone, skin, liver, stomach, intestine and lung. Osteoprotegerin inhibits the recruitment, proliferation and activation of osteoclasts. Osteoclast formation activity may be monitored principally by determination of concentration ratio of osteoprotegerin ligand (OPGL)/OPG. Alteration of this ratio may be the cause of bone loss in many imbalances in bone metabolism such as osteoporosis, osteopetrosis, hypercalcemia, metastatic osteolytic lesions and rheumatic bone degradation.Synonyms: OCIF, OPG, Osteoclastogenesis inhibitory factor, Tumor necrosis factor receptor superfamily member 11B

Gene ID: 4982

NCBI Accession: NP_002537

UniProt: O00300