Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) antibody

Details for Product No. ABIN114706
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Antigen
Synonyms ocif, opg, tr1, OCIF, OPG, TR1, Opg
Reactivity
Human
(62), (4), (3), (1), (1), (1)
Host
Mouse
(40), (12), (5), (4), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(56), (37), (20), (11), (8), (7), (7), (6), (5), (3), (3), (2)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN114706
533.50 $
Plus shipping costs $45.00

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Immunogen Recombinant human Osteoprotegerin (OPG Fc Chimera) produced in E. coli.
Clone OPG-01
Isotype IgG1
Specificity The antibody recognizes human Osteoprotegerin. Other species not tested.
Purification Affinity chromatography on protein G
Alternative Name Osteoprotegerin / TNFRSF11B
Background Osteoprotegerin (OPG) or osteoclastogenesis inhibitory factor (OCIF) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 amino acid residues, it has a molecular weight of 60 kDa as a monomer and 120 kDa as a disulfide-linked dimer and is produced in different tissues, e.g. bone, skin, liver, stomach, intestine and lung. Osteoprotegerin inhibits the recruitment, proliferation and activation of osteoclasts. Osteoclast formation activity may be monitored principally by determination of concentration ratio of osteoprotegerin ligand (OPGL)/OPG. Alteration of this ratio may be the cause of bone loss in many imbalances in bone metabolism such as osteoporosis, osteopetrosis, hypercalcemia, metastatic osteolytic lesions and rheumatic bone degradation.Synonyms: OCIF, OPG, Osteoclastogenesis inhibitory factor, Tumor necrosis factor receptor superfamily member 11B
Gene ID 4982
NCBI Accession NP_002537
UniProt O00300
Application Notes ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 0.1 mL of deionized water. Let the pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
Concentration 1.0 mg/mL
Buffer 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2
Handling Advice Avoid repeated freezing and thawing. Do Not Freeze working dilutions.
Storage -20 °C
Storage Comment Stock solution or aliquots thereof can be kept frozen at -20 °C.
General Simonet, Lacey, Dunstan et al.: "Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. ..." in: Cell, Vol. 89, Issue 2, pp. 309-19, 1997 (PubMed).

Yasuda, Shima, Nakagawa et al.: "Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro." in: Endocrinology, Vol. 139, Issue 3, pp. 1329-37, 1998 (PubMed).

Bolten, Weissbach, Kaden: "[Cryopreserved human sperm deposits: usability after decades of storage]" in: Der Urologe. Ausg. A, Vol. 44, Issue 8, pp. 904-8, 2005 (PubMed).

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