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Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) antibody

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Synonyms ocif, opg, tr1, OCIF, OPG, TR1, Opg
(105), (8), (7), (1), (1), (1)
(72), (23), (6), (4), (1)
Clonality (Clone)
Monoclonal ()
(9), (3), (3), (3), (3), (3), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(89), (58), (39), (16), (11), (9), (9), (8), (8), (2), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant human Osteoprotegerin (OPG Fc Chimera) produced in E. coli.
Clone OPG-01
Isotype IgG1
Specificity The antibody recognizes human Osteoprotegerin. Other species not tested.
Purification Affinity chromatography on protein G
Alternative Name Osteoprotegerin / TNFRSF11B (TNFRSF11B Antibody Abstract)
Background Osteoprotegerin (OPG) or osteoclastogenesis inhibitory factor (OCIF) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 amino acid residues, it has a molecular weight of 60 kDa as a monomer and 120 kDa as a disulfide-linked dimer and is produced in different tissues, e.g. bone, skin, liver, stomach, intestine and lung. Osteoprotegerin inhibits the recruitment, proliferation and activation of osteoclasts. Osteoclast formation activity may be monitored principally by determination of concentration ratio of osteoprotegerin ligand (OPGL)/OPG. Alteration of this ratio may be the cause of bone loss in many imbalances in bone metabolism such as osteoporosis, osteopetrosis, hypercalcemia, metastatic osteolytic lesions and rheumatic bone degradation.Synonyms: OCIF, OPG, Osteoclastogenesis inhibitory factor, Tumor necrosis factor receptor superfamily member 11B
Gene ID 4982
NCBI Accession NP_002537
UniProt O00300
Application Notes ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 0.1 mL of deionized water. Let the pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
Concentration 1.0 mg/mL
Buffer 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2
Handling Advice Avoid repeated freezing and thawing. Do Not Freeze working dilutions.
Storage -20 °C
Storage Comment Stock solution or aliquots thereof can be kept frozen at -20 °C.
Background publications Bolten, Weissbach, Kaden: "[Cryopreserved human sperm deposits: usability after decades of storage]" in: Der Urologe. Ausg. A, Vol. 44, Issue 8, pp. 904-8, 2005 (PubMed).

Yasuda, Shima, Nakagawa et al.: "Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro." in: Endocrinology, Vol. 139, Issue 3, pp. 1329-37, 1998 (PubMed).

Simonet, Lacey, Dunstan et al.: "Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. ..." in: Cell, Vol. 89, Issue 2, pp. 309-19, 1997 (PubMed).

Catalog No. ABIN114706
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