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Chemokine (C-C Motif) Ligand 7 (CCL7) antibody

Details for Product No. ABIN114715, Supplier: Log in to see
Antigen
  • CCL7
  • FIC
  • MARC
  • MCP-3
  • MCP3
  • NC28
  • SCYA6
  • SCYA7
  • Scya7
  • fic
  • marc
  • mcp3
Reactivity
Human
174
26
6
2
Host
Mouse
100
69
28
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
27
14
13
8
6
6
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
145
131
30
19
13
13
9
8
6
6
3
3
3
3
1
1
Supplier
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Immunogen Recombinant human MCP-3 (M.W. 8.5 kDa containing 76 amino acids residues).
Clone 113
Isotype IgG1
Specificity Reactive with natural and recombinant Human MCP-3. Does not show any cross reaction with other Human Cytokines or growth factors tested such as IL1 beta, IL-8, MCAF, SAA and EGF.
Purification Affinity Chromatography on Protein G.
Alternative Name MCP3 / CCL7 (CCL7 Antibody Abstract)
Background Macrophage/monocyte chemotactic protein-3 (MCP-3), like other two closely related chemokines (MCP1 and MCP-2), is chemotactic to monocytes, but not to neutrophils. MCP-3 showed 78 % sequence homology with MCP-1 and 58 % sequence homology with MCP-2. The primary receptor for MCP-3 is D6. MCP-3 also competes with MCP-1 to bind to CCR10, and competes with Rantes and MIP-1α to bind to CCR1. MCP-3 stimulates macrophage to secrete proteases. A variety of cancer cell lines express MCP-3, suggesting a role in tumor invasion and metastasia.Synonyms: C-C motif chemokine 7, CCL-7, MCP-3, Macrophage Chemotactic Protein-3, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3, NC28, SCYA6, SCYA7, Small-inducible cytokine A7
Gene ID 6354
NCBI Accession NP_006264
UniProt P80098
Research Area Cytokines, Chemokines
Pathways
Application Notes ELISA. Western Blot: CCL7 antibody concentration of 1-4 μg/mL will allow visualization of 0.1 μg/lane of human MCP-3. Matched Pair: DM2035 Clone 113DM2039 Clone 542
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with Double distillated water to adjust the final concentration to 1.0 mg/mL
Buffer 0.01 M PBS, pH 7.2 without preservatives
Preservative Without preservative
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store the antibody at 2 - 8 °C. DO NOT FREEZE! If the reagent is being diluted, it is recommended that only the quantity to be used withing one week be diluted.
Background publications Gerdes, Schwab, Lemke et al.: "Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation." in: International journal of cancer. Journal international du cancer, Vol. 31, Issue 1, pp. 13-20, 1983 (PubMed).

Houmand, Abrahamsen, Tinggaard Pedersen: "Relevance of Ki-67 expression in the classification of non-Hodgkin's lymphomas: a morphometric and double-immunostaining study." in: Histopathology, Vol. 20, Issue 1, pp. 13-20, 1992 (PubMed).