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Cardiotrophin 1 antibody

CTF1 Reactivity: Human WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN115501
  • Target See all Cardiotrophin 1 (CTF1) Antibodies
    Cardiotrophin 1 (CTF1)
    Reactivity
    • 72
    • 23
    • 18
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 74
    • 6
    • 1
    Rabbit
    Clonality
    • 75
    • 6
    Polyclonal
    Conjugate
    • 34
    • 13
    • 9
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Cardiotrophin 1 antibody is un-conjugated
    Application
    • 53
    • 31
    • 28
    • 13
    • 13
    • 12
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Sequence
    MRGSHHHHHH GSSRREGSLE DPQTDSSVSL LPHLEAKIRQ THSLAHLLTK YAEQLLQEYV QLQGDPFGLP SFSPPRLPVA GLSAPAPSHA GLPVHERLRL DAAALAALPP LLDAVCRRQA ELNPRAPRLL RRLEDAARQA RALGAAVEAL LAALGAANRG PRAEPPAATA SAASATGVFP AKVLGLRVCG LYREWLSRTE GDLGQLLPGG SA
    Specificity
    This antibody recognizes Human Cardiotrophin-1. Other species not tested.
    Purification
    Immunoaffinity chromatography
    Immunogen
    Recombinant Human Cardiotrophin-1.
    Top Product
    Discover our top product CTF1 Primary Antibody
  • Application Notes
    ELISA. Western Blot.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore with 0.1 mL of deionized water. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
    Concentration
    1.0 mg/mL
    Buffer
    0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE, None
    Preservative
    Azide free
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 months without detectable loss of activity.
    Expiry Date
    6 months
  • Target
    Cardiotrophin 1 (CTF1)
    Alternative Name
    Cardiotrophin-1 (CTF1 Products)
    Synonyms
    CTF1 antibody, ct1 antibody, ct-1 antibody, ctf2 antibody, CT-1 antibody, CT1 antibody, cardiotrophin 1 antibody, cardiotrophin-1 antibody, CTF1 antibody, ctf1 antibody, Ctf1 antibody, LOC100736818 antibody
    Background
    Cardiotrophin-1 (CT-1) is a 201 amino acid member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. CT-1 mRNA levels were found both in cardiac myocytes and in cardiac nonmyocytes. CT-1 was also detected in abundance in normal adult human lung and was expressed in both fetal and adult airway smooth muscle cells. CT-1activates gp130 dependent signaling and stimulates the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes. CT-1 has also a neurotrophic function. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice during a period between embryonic day 14 and the first postnatal week. Moreover, CT-1 is a hepatocyte survival factor that efficiently reduces hepatocellular damage in animal models of acute liver injury. CT-1 expression is augmented after hypoxic stimulation and it can protect cardiac cells when added either prior to simulated ischaemia or at the time of reoxygenation following simulated ischaemia. CT-1 can induce expression of the protective heat shock proteins (hsps) in cardiac cells. Cardiotrophin-1 increased ventricular expression of ANP, brain natriuretic peptide (BNP) and angiotensinogen mRNA. CT-1 levels were significantly elevated in patients with heart failure, patients with dilatative cardiomyopathy, moderate/severe mitral regurgitation, stable and unstable angina and after acute myocardial infarction. Total 212 AA. MW: 22.5 kDa (calculated). N-Terminal His-tag, 12 extra AA (highlighted).Synonyms: CT-1, CTF1
    Gene ID
    1489
    NCBI Accession
    NP_001136016
    UniProt
    Q16619
    Pathways
    JAK-STAT Signaling
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