Podoplanin (PDPN) antibody

Details for Product No. ABIN115686
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Antigen
Synonyms PDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, OTS-8, RANDAM-2, T1-alpha, T1a, T1alpha, E11, RTI40
Reactivity
Human
(118), (46), (19), (1)
Host
Rabbit
(80), (51), (13), (13), (4), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (6), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(95), (44), (41), (37), (32), (24), (24), (22), (8), (8), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.2 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

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Catalog No. ABIN115686
500.50 $
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Immunogen Recombinant ectodomain of human gp36 (Podoplanin)
Specificity This antibody detects Podoplanin.
Purification Protein A affinity chromatography
Alternative Name Podoplanin
Background Podoplanin is a highly O-glycosylated integral membrane protein that is specifically expressed in the endothelium of lymphatic capillaries but not in the blood vasculature. In normal skin and kidney, Podoplanin colocalized with VEGFR-3/FLT4, another marker for lymphatic endothelial cells.
Alternate names: Aggrus, GP36, Glycoprotein 36, PA2.26 antigen, PDPN, PSEC0003, PSEC0025, T1-alpha
Gene ID 10630
NCBI Accession NP_001006625
UniProt Q86YL7
Application Notes Immunoprecipitation: 2-4 µg/sample. Immunofluorescence: 1-2 µg. Western blotting: 1-2 µg/ml). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore in sterile water to a concentration of > 0.5 mg/mL.
Buffer PBS, pH 7.4, without preservative or stabilizer
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment The lyophilized IgG is stable at 2-8°C for one month and for one year from despatch when kept at -20°C. When reconstituted in sterile water to a concentration of > 0.5 mg/ml the antibody is stable for six weeks at 2-8°C in the presence of a preservative. Reconstituted antibody can also be aliquotted and stored at -20°C to -70°C for six months without detectable loss of activity.
Expiry Date 12 months
Product cited in: Conrad, Niess, Huss et al.: "Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo." in: Circulation, Vol. 119, Issue 2, pp. 281-9, 2009 (PubMed).

Background publications Breiteneder-Geleff, Matsui, Soleiman et al.: "Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis." in: The American journal of pathology, Vol. 151, Issue 4, pp. 1141-52, 1997 (PubMed).

Zimmer, Oeffner, Von Messling et al.: "Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium." in: The Biochemical journal, Vol. 341 ( Pt 2), pp. 277-84, 1999 (PubMed).

Schacht, Ramirez, Hong et al.: "T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema." in: The EMBO journal, Vol. 22, Issue 14, pp. 3546-56, 2003 (PubMed).

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