Integrin beta 2 (ITGB2) antibody

Details for Product No. ABIN118151
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Antigen
Synonyms ITGB2, 2E6, AI528527, Cd18, LAD, LCAMB, Lfa1, MF17, CD18, LFA-1, MAC-1, MFI7, AI256028, LTbetaR, Ltar, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFRrp, Tnfbr, Tnfrsf3, D12S370, LT-BETA-R, TNFR3, TNFRSF3
Reactivity
Mouse (Murine)
(265), (187), (99), (62), (53), (46), (36), (24), (1)
Host
Rat
(187), (134), (103), (2), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(60), (42), (32), (14), (12), (7), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(280), (145), (129), (70), (46), (46), (45), (43), (40), (27), (15), (6), (3), (3), (2)
Pubmed 5 references available
Quantity 0.2 mg
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Catalog No. ABIN118151
445.50 $
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Immunogen Cell membrane glycoproteins derived from BW5147 cells (1)
Clone C71-16
Isotype IgG2a
Specificity This antibody is specific for the common beta2subunit of LFA-1 (CD11a/CD18), MAC-1 (CD11b/CD18) and P150,95 (CD11c/CD18) (2,3). These three beta2 integrins, which function in cell-cell adhesion in the immune system, are also known as leukocyte integrins because their expression is limited to leukocytes (2,3).
Purification Purified
Alternative Name CD18 / ITGB2
Background CD18 is an integrin. Integrins are integral cell surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA1, and combines with the alpha M chain to form the integrin Mac1. Integrins are known to participate in cell adhesion as well as cell surface mediated signalling. CD18 is expressed by most leucocytes. Defects in the CD18 gene result in leukocyte adhesion deficiency.
Alternate names: 95 subunit beta, Cell surface adhesion glycoproteins LFA-1/CR3/p150, Complement receptor C3 subunit beta, Integrin beta-2, MFI7
Gene ID 16414
NCBI Accession NP_032430
UniProt P11835
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes IHC on acetone-fixed frozen sections. Immunoprecipitation. Flow cytometry (please see protocol for details). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS and 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store the antibody (undiluted) at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Springer: "Adhesion receptors of the immune system." in: Nature, Vol. 346, Issue 6283, pp. 425-34, 1990 (PubMed).

Larson, Springer: "Structure and function of leukocyte integrins." in: Immunological reviews, Vol. 114, pp. 181-217, 1990 (PubMed).

Springer, Davignon, Ho et al.: "LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function." in: Immunological reviews, Vol. 68, pp. 171-95, 1983 (PubMed).

Trowbridge, Omary: "Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1." in: The Journal of experimental medicine, Vol. 154, Issue 5, pp. 1517-24, 1982 (PubMed).

Springer: "Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm." in: Cell, Vol. 76, Issue 2, pp. 301-14, 1994 (PubMed).

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