Integrin beta 2 antibody (AA 17-382)

Catalog No. ABIN3031376

The Rabbit Polyclonal anti-Integrin beta 2 antibody is suitable to detect Integrin beta 2 in samples from Human, Mouse and Rat. It has been validated for FACS, WB and IHC (p).

Quick Overview for Integrin beta 2 antibody (AA 17-382) (ABIN3031376)

Target: Integrin beta 2 (ITGB2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin beta 2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Integrin beta 2 Antibody

Binding Specificity: AA 17-382

Purpose: MAC-1 Antibody / CD11b / ITGAM

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 17-382) was used as the immunogen for this MAC-1 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the MAC-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. This antibody has shown cross-reactivity with CD11c by ELISA.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MAC-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Alternative Name: MAC-1

Background: Macrophage-1 alpha (MAC-1) or CD11b are glycoproteins encoded by the ITGAM gene. It is mapped to 16p11.2. MAC-1 has a role in vascular repair after mechanical arterial injury. It is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Additionally, it likely recognizes the R-G-D peptide in C3b, and it is also a receptor for fibrinogen, factor X and ICAM1.

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation