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Synaptophysin antibody (SYP)

Details for Product anti-SYP Antibody No. ABIN119030, Supplier: Login to see
Antigen
  • syp-B
  • xsypii
  • MGC86267
  • MRXSYP
  • A230093K24Rik
  • AI848995
  • Syn
  • p38
  • Syp1
  • mrxsyp
  • syp
  • xsypi
Reactivity
Hamster, Human, Pig (Porcine), Rat (Rattus)
251
87
70
29
8
6
3
3
3
2
1
1
1
1
Host
Mouse
188
121
6
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Synaptophysin antibody is un-conjugated
8
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
234
123
84
59
43
32
18
17
12
4
4
4
3
3
1
1
Supplier
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Immunogen Crude human synaptophysin immunoprecipitate. Spleen cells from immunised BALB/c mice were fused with cells of the NSO mouse myeloma cell line.
Clone SP15
Isotype IgM
Specificity This antibody recognises an antigen which appears to be identical to the synaptic vesicle protein synaptophysin. It reacts with synaptophysin expressed in CHO cells (3., 8.).
Purification Gel filtration.
Alternative Name Synaptophysin / SYP (SYP Antibody Abstract)
Background Synonyms: Major synaptic vesicle protein p38, Neuroendocrine Marker
Gene ID 6855
NCBI Accession NP_003170
UniProt P08247
Pathways
Application Notes ELISA. Western Blot: 1/500. Immunohistochemistry on Paraffin Sections: 1/25. Recommended Positive Control: Pancreas.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Simpson, Chundu, Davies-Hill et al.: "Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease." in: Annals of neurology, Vol. 35, Issue 5, pp. 546-51, 1994 (PubMed).

Honer, Beach, Hu et al.: "Hippocampal synaptic pathology in patients with temporal lobe epilepsy." in: Acta neuropathologica, Vol. 87, Issue 2, pp. 202-10, 1994 (PubMed).

Masliah, Honer, Mallory et al.: "Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus." in: Acta neuropathologica, Vol. 87, Issue 2, pp. 135-42, 1994 (PubMed).

Wakabayashi, Honer, Masliah: "Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease." in: Brain research, Vol. 667, Issue 1, pp. 24-32, 1995 (PubMed).

Dickson, Davies, Bevona et al.: "Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans." in: Acta neuropathologica, Vol. 88, Issue 3, pp. 212-21, 1995 (PubMed).

Honer, Hu, Davies: "Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex." in: Brain research, Vol. 609, Issue 1-2, pp. 9-20, 1993 (PubMed).

Honer, Kaufmann, Kleinman et al.: "Monoclonal antibodies to study the brain in schizophrenia." in: Brain research, Vol. 500, Issue 1-2, pp. 379-83, 1990 (PubMed).

Honer, Kaufmann, Davies: "Characterization of a synaptic antigen of interest in neuropsychiatric illness." in: Biological psychiatry, Vol. 31, Issue 2, pp. 147-58, 1992 (PubMed).

Honer, Dickson, Gleeson et al.: "Regional synaptic pathology in Alzheimer's disease." in: Neurobiology of aging, Vol. 13, Issue 3, pp. 375-82, 1992 (PubMed).