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CD2 Molecule (CD2) antibody (Biotin)

Antigen

CD2 Molecule (CD2)

Synonyms T11, SRBC, FLJ46032, CD2, MGC140284, CD2R, LFA2, OX34, LFA-2, OX-34, Ly37, Ly-37
Clonality Monoclonal (LT2)
Host
Alternatives

Mouse

Reactivity
Alternatives

Human

Conjugate
Alternatives Biotin
Application
Alternatives Flow Cytometry (FACS)
2 references available
Catalog no. ABIN119500
Quantity 0.1 mg  (0.1 mg/ml)  (Variants)
Price 370.00 $   Plus shipping costs $35.00
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Additional Information

Alternative name CD2
Swiss-Prot P06729
Immunogen Normal human peripheral blood lymphocytes. Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63.653 myeloma cell line
Isotype IgG2b
Clone LT2
Description CD2 is a receptor for CD58 (LFA-3), and is important in mediating the interaction between T cells and target cells or antigen presenting cells. Alternate Names: CD2, SRBC, T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, T-cell surface antigen CD2.
Specificity This antibody is a single chain transmembrane glycoprotein of 50kD, expressed by T cells, NK cells and thymocytes. This antibody inhibits NK cell mediated cytotoxicity, and ConA and PHA mediated blast transformation.

Application Details

Application Notes Flow cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 0.1 mg/ml
Buffer PBS, pH7.4 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only

Publications

Publications Moingeon, Chang, Sayre et al.: "The structural biology of CD2." in: Immunological reviews, Vol. 111, pp. 111-44, 1990 (PubMed).

Beyers, Barclay, Law et al.: "Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen." in: Immunological reviews, Vol. 111, pp. 59-77, 1990 (PubMed).