CCL2 antibody

Catalog No. ABIN120345

The Mouse Monoclonal anti-CCL2 antibody (Clone 2-2-4A4-1A11) (ABIN120345) specifically detects CCL2 in IHC (p), EIA and ELISA (Detection). The antibody is reactive with Human samples.

Quick Overview for CCL2 antibody (ABIN120345)

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCL2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), ELISA (Detection)

Clone: 2-2-4A4-1A11

Product Details anti-CCL2 Antibody

Purification: Affinity chromatography on Protein A

Immunogen: Recombinant human MCP-1/MCAF (Macrophage Chemoattractant Activating Factor). Spleen cells from immunised BALB/c X ICR F1 mice were fused with cells of a mouse myeloma cell line.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/250 - 1/500 (as detection reagent).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 0.5 mL distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. We recommend that the vial is gently mixed after reconstitution.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: This product is photosensitive and should be protected from light

Storage: 4 °C

Storage Comment: Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Target Details for CCL2

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Alternative Name: MCP1 / CCL2

Background: This chemotactic factor attracts monocytes and basophils but not neutrophils or eosinophils and augments monocyte anti-tumor activity. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. It may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.Synonyms: C-C motif chemokine 2, HC-11, HC11, MCAF, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, Monocyte chemotactic protein 1, Monocyte secretory protein JE, SCYA2, Small-inducible cytokine A2

Gene ID: 9606

UniProt: P13500

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, The Global Phosphorylation Landscape of SARS-CoV-2 Infection