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MGluR1a / GRM1a (Extracell. Dom.) antibody
| Antigen | MGluR1a / GRM1a (Extracell. Dom.) |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Human, Mouse (Murine), Rat (Rattus) |
| Application |
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|
| Catalog no. | ABIN122309 |
| Quantity | 50 µg (1 mg/ml) |
| Price | 430.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Swiss-Prot | Q13255 |
| Immunogen | Synthetic peptide - KLH conjugated |
| Description | The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. mGluR1 has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries. Caution: GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1). Alternate Names: GRM1A, MGLU1, MGLUR1, MGLUR1A, GPRC1A, glutamate receptor, metabotropic 1, grm1, MGLU1 RECEPTOR, mglur1. |
| Specificity | Reacts with Metabotropic Glutamate Receptor 1 (family: GPCR, subfamily: Metabotropic glutamate).The immunizing peptide shows 94 % identity (100 % similarity) with mouse and 94 % identity (100 % similarity) with rat |
Application Details
| Application Notes | Immunohistochemistry with formalin fixed paraffin embedded tissues: 17 ug/ml Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100°C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International. |
| Concentration | 1 mg/ml |
| Buffer | PBS, pH 7.7, containing 0.01% sodium azide |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Restrictions | For Research Use only |
