Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) antibody

Details for Product No. ABIN125958
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Antigen
Synonyms A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, A2mr, AI316852, Lrp, LRP-1
Reactivity
Human
(130), (49), (32), (13), (12), (12), (6), (2), (1)
Host
Mouse
(73), (60)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(14), (11), (7), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
(70), (53), (45), (34), (31), (30), (20), (16), (15), (8), (8), (6), (2), (2), (1), (1)
Pubmed 7 references available
Quantity 50 μg
Shipping to United States (Change)
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Catalog No. ABIN125958
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Immunogen Human LRP/alpha2MR.
Clone 8G1
Isotype IgG1
Specificity 8G1 specifically reacts with the 515 kDa α-chain of human LRP/α2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurones and astrocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocytederived foam cells in atherosclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).
Purification Protein A affinity chromatography
Alternative Name CD91 / LRP1
Background Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.Synonyms: A2MR, APOER, APR, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1
Gene ID 4035
NCBI Accession NP_002323
UniProt Q07954
Research Area CD Antigens, Surface Receptors of Immune Cells, Receptors
Application Notes Immunofluorescence. Immunohistochemistry: 1: 20. Flow cytometry. Immunoblotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore in 1 mL dist. water
Buffer PBS buffer, pH 7.4 containing 0.5 % BSA
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Background publications Wolf, Lopes, VandenBerg et al.: "Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain." in: The American journal of pathology, Vol. 141, Issue 1, pp. 37-42, 1992 (PubMed).

Strickland, Ashcom, Williams et al.: "Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor." in: The Journal of biological chemistry, Vol. 265, Issue 29, pp. 17401-4, 1990 (PubMed).

Coukos, Gåfvels, Wisel et al.: "Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts." in: The American journal of pathology, Vol. 144, Issue 2, pp. 383-92, 1994 (PubMed).

Strickland, Kounnas, Argraves: "LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 9, Issue 10, pp. 890-8, 1995 (PubMed).

Misra, Gawdi, Pizzo: "Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages." in: Archives of biochemistry and biophysics, Vol. 372, Issue 2, pp. 238-47, 2000 (PubMed).

Herz, Strickland: "LRP: a multifunctional scavenger and signaling receptor." in: The Journal of clinical investigation, Vol. 108, Issue 6, pp. 779-84, 2001 (PubMed).

General Rebeck, Reiter, Strickland et al.: "Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions." in: Neuron, Vol. 11, Issue 4, pp. 575-80, 1993 (PubMed).

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