SERPINB9 antibody

Catalog No. ABIN126942

The Mouse Monoclonal anti-SERPINB9 antibody (Clone PI9-17) (ABIN126942) specifically detects SERPINB9 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for SERPINB9 antibody (ABIN126942)

Target: SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SERPINB9 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PI9-17

Product Details anti-SERPINB9 Antibody

Specificity: The antibody clone PI9-17 recognizes 42 kDa native PI-9 and the 63 kDa PI-9 complexed to Granzyme B.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: PI9, Serpin B9, Cytoplasmic antiproteinase 3, CAP-3, CAP3, Proteinase inhibitor 9

Purification: Affinity Chromatography

Immunogen: Recombinant human full length PI9

Isotype: IgG1

Application Details

Application Notes: Western Blot: 2-4 μg/mL. Immunohistochemistry: 20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS, 0.02 % Thimerosal, 50 % Glycerol, 1 % BSA

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for SERPINB9

Target: SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))

Alternative Name: SERPINB9

Background: Proteinase inhibitor 9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis, and is also an inhibitor of capase-1 and, to a smaller extent, caspase-4 and caspase-8. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B, particulary during target cell killling.Synonyms: CAP-3, CAP3, Cytoplasmic antiproteinase 3, PI-9, PI9, Proteinase inhibitor 9, Serpin B9

Gene ID: 5272

UniProt: P50453