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NK-1.1 antibody

Details for Product No. ABIN135340, Supplier: Login to see New
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Synonyms AI462337, CD161, Ly-59, Ly55c, Ly59, NK-RP1, NK1.1, NKR-P1.9, NKRP1, NKRP140, Nk-1, Nk-1.2, Nk1, Nk1.2, Nkrp1c, ly-55c
Mouse (Murine)
(145), (14)
(132), (13), (1)
Clonality (Clone)
Monoclonal ()
(20), (18), (15), (11), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS), Immunoprecipitation (IP)
(119), (37), (16), (12), (11), (10), (10), (7), (6), (5), (5), (2), (2), (2), (2), (2), (2), (1)
Pubmed 4 references available
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Quantity 0.5 mg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen CE mouse spleen and bone marrow cells enriched for NK-1+ cells 1
Clone PK136
Isotype IgG2a
Characteristics The antibody detects: Mouse NK1.1 alloantigen, Mr 80-85 kDa (39 kDa under reducing conditions)
Purification Purified
Alternative Name NK1.1
Background NK1.1, a member of the NKR-P1 family of cell surface receptors, is a type II integral membrane glycoprotein with a C-type lectin domain. It is expressed as a disulfide-linked homodimer on all NK cells, as well as subsets of thymocytes and peripheral T lymphocytes in selected strains of mice (e.g., C57BL, NZB). NK1.1 mediates cellular activation and differentiation, and is thought to have a particular role in generating Th2 cells. This product does not react with NK cells of BALB/c mice.
Application Notes Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Induction of proliferation of a subset of NK cells, In vivo depletion of NK1.1 cells, In vitro redirected lysis, In vitro cytotoxicity assays

Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.
Preservative Azide free
Handling Advice Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
Background publications Routes, Ryan, Ryan et al.: "MHC class I molecules on adenovirus E1A-expressing tumor cells inhibit NK cell killing but not NK cell-mediated tumor rejection." in: International immunology, Vol. 13, Issue 10, pp. 1301-7, 2001 (PubMed).

Lanier: "Natural killer cells: from no receptors to too many." in: Immunity, Vol. 6, Issue 4, pp. 371-8, 1997 (PubMed).

Michie, Streeter, Butcher et al.: "L-selectin and alpha 4 beta 7 integrin homing receptor pathways mediate peripheral lymphocyte traffic to AKR mouse hyperplastic thymus." in: The American journal of pathology, Vol. 147, Issue 2, pp. 412-21, 1995 (PubMed).

Sentman, Hackett, Moore et al.: "Pan natural killer cell monoclonal antibodies and their relationship to the NK1.1 antigen." in: Hybridoma, Vol. 8, Issue 6, pp. 605-14, 1990 (PubMed).

Catalog No. ABIN135340
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