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Details for Product No. ABIN135831

Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody

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Antigen
Synonyms LAMPA, CD107a, LGP120, AI196048, Lamp-1, LEP100
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN135831
Quantity 0.1 mg
Price
135.30 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Clone H4A3
Isotype IgG1
Characteristics The antibody detects: Human CD107a/LAMP-1
Purification Purified
Purity Purified
Alternative Name CD107a/LAMP-1
Background CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.
Application Notes Working Dilution:
FACS: 1 µg/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.
Preservative Azide free
Handling Advice Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
Febbraio, Silverstein: "Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein." in: The Journal of biological chemistry, Vol. 265, Issue 30, pp. 18531-7, 1990 (PubMed).

Chen, Cha, Yuksel et al.: "Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. Sequence similarity to proteins bearing onco-differentiation antigens." in: The Journal of biological chemistry, Vol. 263, Issue 18, pp. 8754-8, 1988 (PubMed).

Sawada, Lowe, Fukuda: "E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels." in: The Journal of biological chemistry, Vol. 268, Issue 17, pp. 12675-81, 1993 (PubMed).

Sawada, Jardine, Fukuda: "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes." in: The Journal of biological chemistry, Vol. 268, Issue 12, pp. 9014-22, 1993 (PubMed).

Alternatives for antigen "Lysosomal-Associated Membrane Protein 1 (LAMP1)", type "Antibodies"
Hosts (81), (60), (34), (1)
Reactivities (125), (75), (40), (9), (7), (6), (3), (2)
Applications (95), (83), (29), (29), (26), (26), (23), (21), (16), (10), (8), (2), (1), (1), (1), (1)
Conjugates (21), (17), (14), (9), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (8), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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