Protein Regulator of Cytokinesis 1 (PRC1) (Middle Region) antibody

Details for Product No. ABIN1449936
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Antigen
Synonyms cb212, prc1, prc1l, zgc:55982, zgc:86918, MGC68845, zgc:55664, ase1, ASE1, D7Ertd348e
Epitope
Middle Region
(7), (6), (4), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(40), (20), (19), (11)
Host
Rabbit
(35), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(31), (19), (9), (6), (5), (3), (3), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN1449936
401.50 $
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Immunogen 19 amino acid synthetic peptide near the center of Human PRC1
Isotype IgG
Specificity At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.
Purification Affinity chromatography purified via peptide column
Alternative Name PRC1
Background PRC1 (Protein Regulator of Cytokinesis 1) is a key regulator of cytokinesis and has been identified as a substrate for several cyclin-dependent kinases (CDKs). High levels of PRC1 expression occurs during S and G2/M and drops dramatically after mitosis exit and G1 entry. It is located in the nucleus during interphase and binds to the midzone of mitotic spindles during anaphase and is localized to the cell midbody during cytokinesis. Depletion of PRC1 has been shown to prevent cellular cleavage, but it has no effect on nuclear division, demonstrating the importance of PRC1 in mitosis.
Alternate names: ASE1, Protein regulator of cytokinesis 1
Gene ID 9055
NCBI Accession NP_003972
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Jiang, Jimenez, Wells et al.: "PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis." in: Molecular cell, Vol. 2, Issue 6, pp. 877-85, 1999 (PubMed).

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