KCP antibody (C-Term)

Catalog No. ABIN1449940

This Rabbit Polyclonal antibody specifically detects KCP in WB and EIA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for KCP antibody (C-Term) (ABIN1449940)

Target: KCP (Kielin/Chordin-Like Protein (KCP))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCP antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-KCP Antibody

Binding Specificity: C-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid synthetic peptide near the carboxy terminus of Human CRIM2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for KCP

Target: KCP (Kielin/Chordin-Like Protein (KCP))

Alternative Name: CRIM2

Background: CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-beta1, suppressing activin- and TGF-beta1-dependent transcription.Synonyms: CRIM-2, Cysteine-rich motor neuron 2 protein, KCP1, NET67, kielin/chordin-like protein

Gene ID: 375616

NCBI Accession: NP_001129386