ZFYVE21 antibody (N-Term)

Catalog No. ABIN1449943

This Rabbit Polyclonal antibody specifically detects ZFYVE21 in WB, IF and EIA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for ZFYVE21 antibody (N-Term) (ABIN1449943)

Target: ZFYVE21 (Zinc Finger, FYVE Domain Containing 21 (ZFYVE21))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFYVE21 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-ZFYVE21 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid synthetic peptide near the amino terminus of Human ZF21

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ZFYVE21

Target: ZFYVE21 (Zinc Finger, FYVE Domain Containing 21 (ZFYVE21))

Alternative Name: ZFYVE21

Background: ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.Synonyms: Zinc finger FYVE domain-containing protein 21

Gene ID: 79038

NCBI Accession: NP_001185882