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Details for Product No. ABIN1449966

Caspase Recruitment Domain Family, Member 14 (CARD14) (C-Term) antibody

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Antigen
Synonyms BIMP2, CARMA2, PRP, PSORS2, PSS1, Bimp2
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
Pubmed 4 references available
Catalog no. ABIN1449966
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen 14 amino acid synthetic peptide near the carboxy terminus of Human CARMA2
Isotype IgG
Specificity At least three isoforms of CARMA2 are known to exist. This antibody will only detect isoform 1 and is predicted not to cross-react with other CARMA proteins.
Purification Affinity Chromatography purified via peptide column
Alternative Name CARD14 / CARMA2
Background CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein activated NF-kB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-kB activation and endoplasmic reticulum stress-induced cell death.
Alternate names: CARD-containing MAGUK protein 2, Caspase recruitment domain-containing protein 14
Gene ID 79092
NCBI Accession NP_077015.2
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Fanning, Anderson: "Protein modules as organizers of membrane structure." in: Current opinion in cell biology, Vol. 11, Issue 4, pp. 432-9, 1999 (PubMed).

Bertin, Wang, Guo et al.: "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 15, pp. 11877-82, 2001 (PubMed).

Gaide, Martinon, Micheau et al.: "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation." in: FEBS letters, Vol. 496, Issue 2-3, pp. 121-7, 2001 (PubMed).

Scudiero, Zotti, Ferravante et al.: "Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-κB activation and endoplasmic reticulum stress-induced cell death." in: Journal of cellular physiology, Vol. 226, Issue 12, pp. 3121-31, 2011 (PubMed).

Alternatives for antigen "Caspase Recruitment Domain Family, Member 14 (CARD14)", type "Antibodies"
Hosts (23), (3)
Reactivities (25), (14), (13)
Applications (13), (9), (7), (6), (5), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (3), (1), (1)
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