Caspase Recruitment Domain Family, Member 14 (CARD14) (C-Term) antibody

Details for Product No. ABIN1449966
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Synonyms BIMP2, CARMA2, PRP, PSORS2, PSS1, Bimp2
(7), (5), (3), (2), (2), (1), (1), (1), (1)
(42), (22), (17)
(34), (6), (5)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(22), (19), (10), (8), (6), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
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Immunogen 14 amino acid synthetic peptide near the carboxy terminus of Human CARMA2
Isotype IgG
Purification Affinity Chromatography purified via peptide column
Alternative Name CARD14 / CARMA2 (CARD14 Antibody Abstract)
Background CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein activated NF-kB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-kB activation and endoplasmic reticulum stress-induced cell death.Synonyms: CARD-containing MAGUK protein 2, Caspase recruitment domain-containing protein 14
Gene ID 79092
NCBI Accession NP_077015
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Scudiero, Zotti, Ferravante et al.: "Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-κB activation and endoplasmic reticulum stress-induced cell death." in: Journal of cellular physiology, Vol. 226, Issue 12, pp. 3121-31, 2011 (PubMed).

Gaide, Martinon, Micheau et al.: "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation." in: FEBS letters, Vol. 496, Issue 2-3, pp. 121-7, 2001 (PubMed).

Bertin, Wang, Guo et al.: "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 15, pp. 11877-82, 2001 (PubMed).

Fanning, Anderson: "Protein modules as organizers of membrane structure." in: Current opinion in cell biology, Vol. 11, Issue 4, pp. 432-9, 1999 (PubMed).

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Catalog No. ABIN1449966
$ 401.50
Plus shipping costs $45.00
0.1 mg
$ 401.50

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