RGS22 antibody (N-Term)

Catalog No. ABIN1449995

The Rabbit Polyclonal anti-RGS22 antibody is suitable to detect RGS22 in samples from Human, Mouse and Rat. It has been validated for WB, IF and EIA.

Quick Overview for RGS22 antibody (N-Term) (ABIN1449995)

Target: RGS22 (Regulator of G-Protein Signaling 22 (RGS22))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS22 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-RGS22 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: A 19 amino acid synthetic peptide near the amino terminus of Human RGS22

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RGS22

Target: RGS22 (Regulator of G-Protein Signaling 22 (RGS22))

Alternative Name: RGS22

Background: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit (1,2). RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.Synonyms: Regulator of G-protein signaling 22

Molecular Weight: 139 kDa

Gene ID: 26166

NCBI Accession: NP_056483

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling