UHRF1 Binding Protein 1 (UHRF1BP1) (Middle Region) antibody

Details for Product No. ABIN1450049
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Antigen
Synonyms C6orf107, UHRF1BP1, c6orf107, si:ch73-90n13.2, 1110020K19Rik, AA408674, F830021D11Rik, mKIAA4127, ICBP90, dJ349A12.1
Epitope
Middle Region
(4), (1), (1)
Reactivity
Human, Mouse (Murine)
(6), (5)
Host
Rabbit
(6)
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(6), (6), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN1450049
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Immunogen 17 amino acid synthetic peptide near the center of Human UHRF1BP1
Isotype IgG
Specificity This UHRF1BP1 antibody is predicted not to cross-react with UHRF1BP1L-.
Purification Affinity chromatography purified via peptide column
Alternative Name UHRF1BP1
Background The Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1 (UHRF1BP1), also known as ICBP90, is a transcription and cell cycle regulator. It specifically binds to the histone H3 N-terminal tail when methylated on K9 by two functional domains, a PHD finger that defines the binding specificity and an SRA (SET- and RING-associated) domain that promotes binding activity. UHRF1BP1 is required for proper heterochromatin formation in mammalian cells. Furthermore, UHRF1BP1 is thought to be a pivotal target for the ERK1/2 signaling pathway to control the proliferation of Jurkat T cells.
Alternate names: ICBP90-binding protein 1, UHRF1 binding protein 1, Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1
Gene ID 54887
NCBI Accession NP_060224
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Hopfner, Mousli, Jeltsch et al.: "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression." in: Cancer research, Vol. 60, Issue 1, pp. 121-8, 2000 (PubMed).

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