anti-Transglutaminase 5 antibody (TGM5) (C-Term)

Details for Product anti-TGM5 Antibody No. ABIN1450065
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Antigen
Synonyms TGM5, TGASE5, TGASEX, TGMX, TGX, 2310007C07Rik, TGx
Epitope
C-Term
(23), (15), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(42), (4), (3), (1), (1)
Host
Rabbit
(41), (1)
Clonality
Polyclonal
Conjugate
This Transglutaminase 5 antibody is un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(40), (24), (11), (3), (3), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
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Immunogen 19 amino acid synthetic peptide near the carboxy terminus of Human TGM5
Isotype IgG
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Rat.
Purification Affinity chromatography purified via peptide column
Alternative Name Transglutaminase-5 (TGM5) (TGM5 Antibody Abstract)
Background Transglutaminases (TGM) are a family of structurally and functionally related Ca2+-dependent enzymes (TGases) that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. TGases influence numerous biological processes, including blood coagulation, cell differentiation, fertilization and apoptosis. TGM5 belongs to the transglutaminase superfamily and catalyzes the cross-linking of proteins between glutamine and lysine residues, often resulting in stabilization of protein assemblies. TGM5 is also expressed in the human hair follicle. Defects in TGM5 are associated with acral peeling skin syndrome.Synonyms: Protein-glutamine gamma-glutamyltransferase 5, TGMX, TGX, TGase 5, TGase X, Transglutaminase X
Gene ID 9333
NCBI Accession NP_963925
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Dewaele, Rasschaert, Wildemauwe et al.: "Polyphasic characterization of Salmonella Enteritidis isolates on persistently contaminated layer farms during the implementation of a national control program with obligatory vaccination: a longitudinal study." in: Poultry science, Vol. 91, Issue 11, pp. 2727-35, 2012 (PubMed).

Cassidy, van Steensel, Steijlen et al.: "A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome." in: American journal of human genetics, Vol. 77, Issue 6, pp. 909-17, 2005 (PubMed).

Thibaut, Candi, Pietroni et al.: "Transglutaminase 5 expression in human hair follicle." in: The Journal of investigative dermatology, Vol. 125, Issue 3, pp. 581-5, 2005 (PubMed).

Candi, Oddi, Terrinoni et al.: "Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro." in: The Journal of biological chemistry, Vol. 276, Issue 37, pp. 35014-23, 2001 (PubMed).

Ueki, Takagi, Saito: "Dual functions of transglutaminase in novel cell adhesion." in: Journal of cell science, Vol. 109 ( Pt 11), pp. 2727-35, 1997 (PubMed).

Validation Images
Catalog No. ABIN1450065
401.50 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
401.50 $

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