PRICKLE2 antibody (Middle Region)

Catalog No. ABIN1450075

This Rabbit Polyclonal antibody specifically detects PRICKLE2 in WB, IF and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PRICKLE2 antibody (Middle Region) (ABIN1450075)

Target: PRICKLE2 (Prickle Homolog 2 (PRICKLE2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRICKLE2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-PRICKLE2 Antibody

Binding Specificity: Middle Region

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid synthetic peptide near the center of human PRICKLE2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PRICKLE2

Target: PRICKLE2 (Prickle Homolog 2 (PRICKLE2))

Alternative Name: PRICKLE2

Background: PRICKLE2, also known as Pk2 or EPM5, is a member of a highly conserved protein family that function in the noncanonical WNT signaling pathway which regulates intracellular calcium release and planar cell polarity. Both PRICKLE2 and the related protein PRICKLE1 are expressed in postmitotic neurons and promote neurite outgrowth, and both proteins promote neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. PRICKLE2 localizes to the postsynaptic density and interacts with PSD-95 and NMDA receptors. Defects in the gene encoding PRICKLE2 are associated with autosomal recessive progressive myoclonic epilepsy.Synonyms: PRICKLE-2, Prickle-like protein 2

Gene ID: 166336

NCBI Accession: NP_942559