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NKX2-1 antibody (N-Term)
NKX2-1
Reactivity: Human, Mouse, Rat
WB, IF, IHC (p), EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-NKX2-1 Antibody
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Target
See all NKX2-1 Antibodies
NKX2-1
(NK2 Homeobox 1 (NKX2-1))
Binding Specificity
All epitopes for NKX2-1 antibodies
N-Term
Reactivity
All reactivities for NKX2-1 antibodies
Human, Mouse, Rat
Host
All hosts for NKX2-1 antibodies
Rabbit
Clonality
All clonalities for NKX2-1 antibodies
Polyclonal
Conjugate
All conjugates for NKX2-1 antibodies
This NKX2-1 antibody is un-conjugated
Application
All applications for NKX2-1 antibodies
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Cross-Reactivity (Details)
Species reactivity (tested):Human, Mouse, Rat.
Purification
Affinity chromatography purified via peptide column
Immunogen
16 amino acid synthetic peptide near the amino terminus of Human NKX2-1
Isotype
IgG
Top Product
Discover our top product NKX2-1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS containing 0.02 % Sodium Azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for NKX2-1
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Target
NKX2-1
(NK2 Homeobox 1 (NKX2-1))
Alternative Name
TTF1 / NKX2A (NKX2-1 Products )
Synonyms
BCH antibody, BHC antibody, NK-2 antibody, NKX2.1 antibody, NKX2A antibody, TEBP antibody, TITF1 antibody, TTF-1 antibody, TTF1 antibody, titf1-A antibody, Xnkx-2.1 antibody, NKX2-1 antibody, LOC100227803 antibody, AV026640 antibody, Nkx2.1 antibody, T/EBP antibody, Titf1 antibody, Ttf-1 antibody, nk2.1a antibody, nkx2.1 antibody, nkx2.4a antibody, titf1 antibody, titf1a antibody, NK2 homeobox 1 antibody, NK2 homeobox 1 L homeolog antibody, NK2 homeobox 4b antibody, NKX2-1 antibody, nkx2-1.L antibody, Nkx2-1 antibody, nkx2.4b antibody
Background
NKX2-1 (NK2 homeobox 1) has been identified as a thyroid-specific transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype and morphogenesis. It contains one homeobox DNA-binding domain. NKX2-1 also may play a role in lung development and surfactant homeostasis. Mutations and deletions in this gene are associated with benign hereditary chorea, congenital hypothyroidism, neonatal respiratory distress, and may be associated with thyroid cancer. NKX2-1 has been suggested to be a candidate suppressor of malignant progression.Synonyms: Homeobox protein NK-2 homolog A, Homeobox protein Nkx-2.1, NKX2-1, Nkx-2.1, TITF1, TTF-1, Thyroid nuclear factor 1, Thyroid transcription factor 1
Gene ID
7080
UniProt
P43699
Pathways
Intracellular Steroid Hormone Receptor Signaling Pathway , Regulation of Systemic Arterial Blood Pressure by Hormones , Cellular Glucan Metabolic Process , Feeding Behaviour
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