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Details for Product No. ABIN179723

Chemokine (C-C Motif) Receptor 4 (CCR4) antibody

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Antigen
Synonyms CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, C-C CKR-4, CHEMR1, Cmkbr4, LESTR, Sdf1r
Reactivity
»Alternatives Human
Host
»Alternatives Mouse (Murine)
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Cell-ELISA (cELISA)
Pubmed 5 references available
Catalog no. ABIN179723
Quantity 100 µg
Price
450.12 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 6 Business Days
Immunogen immunisation with human CCR4 peptide
Clone KH-4F5
Isotype IgG2a
Specificity Anti-human CCR4
Purification Protein G
Alternative Name CCR4
Background CCR4 (CC chemokine receptor 4) molecule belongs to the rhodopsin family of G-protein-coupled receptors. Chemokine receptors are membrane bound molecules composed of 7-transmembrane domains and coupled to G-proteins. CCR4 binds the chemokines CCL17 (TARC) and CCL22 (MDC) and is highly expressed in most single-positive CD4(+) thymocytes especially in TH2- and regulatory T-cells. It plays a central role in T cell migration to the thymus, T cell maturation and education. CCR4 is often up-regulated in inflammation and cause conformational changes that trigger intracellular signaling pathways.
UniProt P51679
Research Area Cardiovascular, Atherosclerosis, Innate Immunity, Chemokines, Receptors
Application Notes Flow cytometry: 1.2 µg/10^6 cells
Immunofluorescence: 1 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.
Comment

Synonyms: CC chemokine receptor 4

Restrictions For Research Use only
Concentration 2 mg/mL
Buffer PBS, pH 7.2
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C
Storage Comment short term: 2 °C - 8 °C, long term: -20 °C
Imai, Baba, Nishimura et al.: "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4." in: The Journal of biological chemistry, Vol. 272, Issue 23, pp. 15036-42, 1997 (PubMed).

Imai, Chantry, Raport et al.: "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4." in: The Journal of biological chemistry, Vol. 273, Issue 3, pp. 1764-8, 1998 (PubMed).

Murdoch, Finn: "Chemokine receptors and their role in inflammation and infectious diseases." in: Blood, Vol. 95, Issue 10, pp. 3032-43, 2000 (PubMed).

Andrew, Ruffing, Kim et al.: "C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 103-11, 2001 (PubMed).

Purandare, Somerville: "Antagonists of CCR4 as immunomodulatory agents." in: Current topics in medicinal chemistry, Vol. 6, Issue 13, pp. 1335-44, 2006 (PubMed).

Alternatives for antigen "Chemokine (C-C Motif) Receptor 4 (CCR4)", type "Antibodies"
Hosts (60), (11), (4)
Reactivities (61), (31), (21), (4), (2), (2), (1), (1), (1)
Applications (40), (37), (26), (13), (10), (10), (6), (5), (3), (2), (2), (2), (1)
Conjugates (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (9), (4), (4), (2), (2), (2), (2), (2), (1), (1)
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