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Chemokine (C-C Motif) Receptor 4 (CCR4) antibody

Details for Product No. ABIN179723, Supplier: Login to see
Antigen
  • A230103N10Rik
  • AA407540
  • AW456442
  • CCR4
  • RGD1310783
  • CC-CKR-4
  • CD194
  • CKR4
  • CMKBR4
  • ChemR13
  • HGCN:14099
  • K5-5
  • C-C CKR-4
  • CHEMR1
  • Cmkbr4
  • LESTR
  • Sdf1r
Reactivity
Human
136
54
24
6
5
2
2
2
Host
Mouse
107
29
19
9
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
9
7
6
5
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Cell-ELISA (cELISA), Flow Cytometry (FACS)
86
67
48
32
27
13
12
8
7
6
6
5
3
2
2
2
1
Supplier
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Immunogen immunisation with human CCR4 peptide
Clone KH-4F5
Isotype IgG2a
Specificity Anti-human CCR4
Purification Protein G
Alternative Name CCR4 (CCR4 Antibody Abstract)
Background CCR4 (CC chemokine receptor 4) molecule belongs to the rhodopsin family of G-protein-coupled receptors. Chemokine receptors are membrane bound molecules composed of 7-transmembrane domains and coupled to G-proteins. CCR4 binds the chemokines CCL17 (TARC) and CCL22 (MDC) and is highly expressed in most single-positive CD4(+) thymocytes especially in TH2- and regulatory T-cells. It plays a central role in T cell migration to the thymus, T cell maturation and education. CCR4 is often up-regulated in inflammation and cause conformational changes that trigger intracellular signaling pathways.
UniProt P51679
Research Area Cardiovascular, Atherosclerosis, Innate Immunity, Chemokines, Receptors
Pathways
Application Notes Flow cytometry: 1.2 µg/10^6 cells
Immunofluorescence: 1 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.
Comment

Synonyms: CC chemokine receptor 4

Restrictions For Research Use only
Concentration 2 mg/mL
Buffer PBS, pH 7.2
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C
Storage Comment short term: 2 °C - 8 °C, long term: -20 °C
Supplier Images
 image for anti-Chemokine (C-C Motif) Receptor 4 (CCR4) antibody (ABIN179723) FACS analysis of BOSC23 cells using KH-4F5. BOSC23 cells were transientlytransfected ...
 image for anti-Chemokine (C-C Motif) Receptor 4 (CCR4) antibody (ABIN179723) Spectral Confocal Microscopy of CHO cells using KH-4F5. CHO cells were transiently tr...
 image for anti-Chemokine (C-C Motif) Receptor 4 (CCR4) antibody (ABIN179723) SDS-PAGE analysis of purified KH-4F5 monoclonal antibody. Lane 1: molecular weight ma...
SDS-PAGE (SDS) image for anti-Chemokine (C-C Motif) Receptor 4 (CCR4) antibody (ABIN179723) SDS-PAGE analysis of purified KH-4F5 monoclonal antibody. Lane 1: molecular weight ma...
Flow Cytometry (FACS) image for anti-Chemokine (C-C Motif) Receptor 4 (CCR4) antibody (ABIN179723) FACS analysis of BOSC23 cells using KH- 4F5. BOSC23 cells were transiently transfecte...
Immunofluorescence (IF) image for anti-Chemokine (C-C Motif) Receptor 4 (CCR4) antibody (ABIN179723) Spectral Confocal Microscopy of CHO cells using KH-4F5. CHO cells were transiently tr...
Background publications Purandare, Somerville: "Antagonists of CCR4 as immunomodulatory agents." in: Current topics in medicinal chemistry, Vol. 6, Issue 13, pp. 1335-44, 2006 (PubMed).

Andrew, Ruffing, Kim et al.: "C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 103-11, 2001 (PubMed).

Murdoch, Finn: "Chemokine receptors and their role in inflammation and infectious diseases." in: Blood, Vol. 95, Issue 10, pp. 3032-43, 2000 (PubMed).

Imai, Chantry, Raport et al.: "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4." in: The Journal of biological chemistry, Vol. 273, Issue 3, pp. 1764-8, 1998 (PubMed).

Imai, Baba, Nishimura et al.: "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4." in: The Journal of biological chemistry, Vol. 272, Issue 23, pp. 15036-42, 1997 (PubMed).