Podoplanin (PDPN) antibody

Details for Product No. ABIN180933
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Antigen
Synonyms PDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, OTS-8, RANDAM-2, T1-alpha, T1a, T1alpha, E11, RTI40
Reactivity
Human
(125), (47), (19), (1)
Host
Mouse
(83), (54), (14), (13), (4), (4), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (6), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(103), (46), (42), (42), (32), (26), (24), (22), (9), (9), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN180933
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Immunogen ORF Human podoplanin ectodomain expressed in E. coliPage 1 of 3.
Clone 4D5aE5E6
Isotype IgG1
Characteristics Synonyms: Glycoprotein 36, PA2.26 antigen, T1-alpha, Aggrus, PDPN, GP36, PSEC0003, PSEC0025
Purification Affinity chromatography on Protein G
Alternative Name Podoplanin
Background Podoplanin a 36kDa type I cell membrane-associated glycoprotein, with a broad spectrumof distribution, being strongly expressed on the lymphatic endothelium found in lung,placenta and skeletal muscle and to a lesser extent in brain, kidney and liver. Podoplaninis absent on blood endothelium and therefore This antibody is readily able to distinguishbetween lymphatic vessels and blood vasculature. Although the specific function of thisprotein is undetermined, Podoplanin is reported to be a reliable indicator of tumourlymphangiogenesis.
UniProt Q86YL7
Application Notes Immunohistochemistry on frozen sections: 0.75g/ml - 2g/ml. Immunohistochemistry on paraffin sections: This product requires antigen retrieval usingheat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 isrecommended for this purpose. Recommended Positive Control: Normal lungOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS containing 0,09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Zimmer, Oeffner, Von Messling et al.: "Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium." in: The Biochemical journal, Vol. 341 ( Pt 2), pp. 277-84, 1999 (PubMed).

Dadras, Paul, Bertoncini et al.: "Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival." in: The American journal of pathology, Vol. 162, Issue 6, pp. 1951-60, 2003 (PubMed).

Schacht, Ramirez, Hong et al.: "T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema." in: The EMBO journal, Vol. 22, Issue 14, pp. 3546-56, 2003 (PubMed).

Matsui, Nagy-Bojarsky, Laakkonen et al.: "Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels." in: Journal of the American Society of Nephrology : JASN, Vol. 14, Issue 8, pp. 1981-9, 2003 (PubMed).

Kato, Fujita, Kunita et al.: "Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 51599-605, 2003 (PubMed).

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