TRAIL antibody (AA 95-281)

Catalog No. ABIN6796422

Product Details anti-TRAIL Antibody

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Binding Specificity: AA 95-281

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TRAIL antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Functional Studies (Func)

Specificity: TRAIL is a cytotoxic protein closely related to Fas (CD95), which induces extensive apoptosis in a range of cell types. TRAIL induces apoptosis via the receptors DR4 and DR5. Most normal tissues are resistant to TRAIL induced apoptosis due to their expression of decoy receptors, DcR1 and DcR2, which antagonize TRAIL activity. TRAIL is expressed by cell lines, activated lymphocytes and on syncytiotrophoblast cells in first trimester pregnancy. This antibody neutralizes TRAIL activity.

Purification: Protein A purified

Immunogen: Recombinant human CD253 (TRAIL) aa 95-281.
ImmunogenType: Recombinant protein

Clone: 2E5

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: PBS

Storage: -20 °C

Storage Comment: Store at -20°C.

Target Details for TRAIL

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Alternative Name: TNFSF10 / TRAIL (TNFSF10 Products)

Background: Synonyms :
TNFSF10, Apo-2L, APO2L, Apo-2 ligand, CD253, CD253 antigen, TRAIL, Protein TRAIL, TL2

Gene ID: 8743

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity