NCOR1 antibody (N-Term)

Catalog No. ABIN182587

This Rabbit Polyclonal antibody specifically detects NCOR1 in IHC and WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Guinea Pig, Horse, Cow and Saccharomyces cerevisiae.

Quick Overview for NCOR1 antibody (N-Term) (ABIN182587)

Target: NCOR1 (Nuclear Receptor Co-Repressor 1 (NCOR1))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Cow, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOR1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-NCOR1 Antibody

Binding Specificity: N-Term

Sequence: NENYKALVRR NYGKRRGRNQ QIARPSQEEK VEEKEEDKAE KTEKKEEEKK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 100%, Rat: 92%, Yeast: 85%

Characteristics: This is a rabbit polyclonal antibody against NCOR1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NCOR1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2453 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NCOR1

Target: NCOR1 (Nuclear Receptor Co-Repressor 1 (NCOR1))

Alternative Name: NCOR1

Background: NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p.
Alias Symbols: N-CoR, TRAC1, N-CoR1, hN-CoR
Protein Interaction Partner: RARA, TP53, ESR1, PHB2, ZBTB16, THRB, THRA, CREB1, JUN, PPARG, SQSTM1, HDAC3, UBE2I, SOX2, HDAC7, HDAC5, HDAC4, UBC, SKIL, SKI, AR, SMAD4, CSNK2A1, RUNX1T1, CXADR, TBL1XR1, vif, C1D, CHUK, YWHAZ, SMARCE1, SMARCD1, SMARCA2, RBBP4, BPTF, HMGXB4, TAB2, NCOR2
Protein Size: 2453

Molecular Weight: 270 kDa

Gene ID: 9611

UniProt: Q60974

Pathways: Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process