WWTR1 antibody (N-Term)

Catalog No. ABIN182600

The Rabbit Polyclonal anti-WWTR1 antibody is suitable to detect WWTR1 in samples from Human, Mouse, Rat, Dog, Cow, Guinea Pig and Rabbit. It has been validated for WB.

Quick Overview for WWTR1 antibody (N-Term) (ABIN182600)

Target: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WWTR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WWTR1 Antibody

Binding Specificity: N-Term

Purpose: WWTR1 Antibody - N-terminal region

Sequence: PRLAGGAQHV RSHSSPASLQ LGTGAGAAGS PAQQHAHLRQ QSYDVTDELP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against WWTR1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human WWTR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32540-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for WWTR1

Target: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Alternative Name: WWTR1

Background:

Background Information: TAZ (transctiptional coactivator with PDZ-binding motif), also known as WW domain containing transcription regulator 1 (WWTR1), is a member of the bicoid sub-family of homeodomain-containing transcription factors. TAZ is a 14-3-3 binding protein that co-activates Runx2-dependent gene transcription while repressing PPAR-gamma-dependent gene transcription. TAZ has been reported to be a modulator of mesenchymal stem cell differentiation. TAZ may also play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.

Gene Name: WW domain containing transcription regulator 1

Alternative Symbols: TAZ

Protein Name: WW domain-containing transcription regulator protein 1

Molecular Weight: 44 kDa

Gene ID: 25937

NCBI Accession: NP_056287

UniProt: Q9GZV5

Pathways: Regulation of Lipid Metabolism by PPARalpha