FOXN3 antibody (C-Term)

Catalog No. ABIN182688

Cited in 1 publication. The Rabbit Polyclonal anti-FOXN3 antibody (ABIN182688) specifically detects FOXN3 in WB. The antibody is reactive with Human, Mouse, Guinea Pig, Horse, Rat, Dog, Rabbit and Zebrafish (Danio rerio) samples.

Quick Overview for FOXN3 antibody (C-Term) (ABIN182688)

Target: FOXN3 (Forkhead Box N3 (FOXN3))

Reactivity: Human, Mouse, Guinea Pig, Horse, Rat, Dog, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXN3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FOXN3 Antibody

Binding Specificity: C-Term

Purpose: CHES1 Antibody - C-terminal region

Sequence: SGYASQHKKR QHFAKARKVP SDTLPLKKRR TEKPPESDDE EMKEAAGSLL

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CHES1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CHES1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8100911

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-FOXN3 antibody (ABIN182688)

Huot, Vernier, Bourdeau, Doucet, Saint-Germain, Gaumont-Leclerc, Moro, Ferbeyre: "CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis." in: Molecular biology of the cell, Vol. 25, Issue 5, pp. 554-65, (2014) (PubMed).

Target Details for FOXN3

Target: FOXN3 (Forkhead Box N3 (FOXN3))

Alternative Name: CHES1

Background:

Background Information: Checkpoint suppressor 1 is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway.

Gene Name: Forkhead box N3

Alternative Symbols: CHES1, PRO1635, C14orf116

Protein Name: Forkhead box protein N3

Molecular Weight: 52kDa

Gene ID: 1112

NCBI Accession: NP_005188

UniProt: O00409