SNAIL antibody (N-Term)

Catalog No. ABIN182776

This Rabbit Polyclonal antibody specifically detects SNAIL in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat and Guinea Pig and has been mentioned in 4+ publications.

Quick Overview for SNAIL antibody (N-Term) (ABIN182776)

Target: SNAIL (SNAI1)

Reactivity: Human, Mouse, Rat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SNAIL Antibody

Binding Specificity: N-Term

Sequence: MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL

Predicted Reactivity: Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SNAI1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SNAI1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 264 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SNAIL antibody (ABIN182776)

He, Lu, Hu, Zhang, Qin, Wang, Xing, Xi, Wang: "The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation." in: International journal of molecular sciences, Vol. 16, Issue 7, pp. 16313-29, (2016) (PubMed).

Sihto, Lundin, Lundin, Lehtimäki, Ristimäki, Holli, Sailas, Kataja, Turpeenniemi-Hujanen, Isola, Heikkilä, Joensuu: "Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study." in: Breast cancer research : BCR, Vol. 13, Issue 5, pp. R87, (2012) (PubMed).

Surati, Robinson, Nandi, Faoro, Demchuk, Rolle, Kanteti, Ferguson, Hasina, Gangadhar, Salama, Arif, Kirchner, Mendonca, Campbell, Limvorasak, Villaflor, Hensing, Krausz, Vokes, Husain, Ferguson et al.: "Proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database. ..." in: Journal of clinical bioinformatics, Vol. 1, Issue 8, pp. 1-11, (2011) (PubMed).

Wang, Quah, Dong, Manser, Tang, Zeng: "PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition." in: Cancer research, Vol. 67, Issue 7, pp. 2922-6, (2007) (PubMed).

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI1

Background: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.
Alias Symbols: SNA, SNAH, SNAIL, SLUGH2, SNAIL1, dJ710H13.1
Protein Interaction Partner: MTUS2, KRT31, TRIM23, ACTN2, MID2, NOTCH2NL, KRTAP10-3, KRT40, FBXL5, EZH2, RNF2, RING1, LATS2, UBC, BTRC, TP53, MDM2, GSK3B, HDAC1, CHD4, KDM1A, HDAC3, HDAC2, RCOR1, FBXL14, NOTCH1, HIST1H3A, EGR1, AJUBA, Sin3a, HOXD4, SUZ12, CTDSP1, CTDSPL, CTDSP2, QRIC
Protein Size: 264

Molecular Weight: 29 kDa

Gene ID: 6615

NCBI Accession: NM_005985, NP_005976

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling