CBFA2T3 antibody (N-Term)

Catalog No. ABIN182912

The Rabbit Polyclonal anti-CBFA2T3 antibody is suitable to detect CBFA2T3 in samples from Human, Mouse, Rat, Guinea Pig, Horse, Cow and Dog. It has been validated for WB.

Quick Overview for CBFA2T3 antibody (N-Term) (ABIN182912)

Target: CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))

Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBFA2T3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CBFA2T3 Antibody

Binding Specificity: N-Term

Sequence: QPRSTPPSMP PPPPAASQGA TRPPSFTPHT LMNGSSHSPT AINGAPCTPN

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 100%, Horse: 85%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CBFA2T3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CBFA2T3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 567 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CBFA2T3

Target: CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))

Alternative Name: CBFA2T3

Background: The t(16,21)(q24,q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of CBFA2T3. In addition, CBFA2T3 is a putative breast tumor suppressor.
Alias Symbols: ETO2, MTG16, MTGR2, ZMYND4
Protein Interaction Partner: Zbtb38, Zbtb4, ZBTB33, GMEB2, SEC24A, MATN2, ZBTB47, UBC, RUNX1, TAL1, TRIM33, SIN3B, NCOR1, HDAC3, CBFA2T3, CBFA2T2, HDAC1, PRKAR2A, RUNX1T1, LDB1, TCF3, HDAC8, HDAC6, HDAC2,
Protein Size: 567

Molecular Weight: 62 kDa

Gene ID: 863

NCBI Accession: NM_175931, NP_787127

UniProt: O75082