Sodium Channel, Nonvoltage-Gated 1 beta (SCNN1B) antibody

Antigen: Sodium Channel, Nonvoltage-Gated 1 beta (SCNN1B)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Cow (Bovine), Human, Dog (Canine), Mouse (Murine), Rat (Rattus), Rabbit

Application: Western Blotting (WB)

Catalog no.: ABIN183112

Additional Information

Alternative name: ENAC beta / SCNN1B

Gene ID: SCNN1B

UniProt: P51168

Immunogen: The immunogen for anti-SCNN1B antibody: synthetic peptide directed towards the C terminal of human SCNN1B

Sequence: QPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDV IESDSEGDAI

Cross-Reactivity: Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rabbit, Rat (Rattus)

Format: Lyophilized

Reconstitution: Add 50 µl of distilled water. Final anti-SCNN1B antibody concentration is 1 mg/ml.

Description: When expressed in the bladder epithelium, the protein encoded by the SCNN1B gene might be implicated in the mechanosensory transduction in the bladder afferent pathways, thereby inducing detrusor instability by outlet obstruction. Common variants of this gene confer susceptibility to human essential hypertension.

Characteristics: Antigen Size: 640 amino acids

Molecular Weight: 70kDa

Application Details

Application Notes: WB Suggested Anti-SCNN1B Antibody Titration: 0.125ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysate.

Purification: Affinity Purified

Buffer: PBS

Storage (Long Term): For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Storage (Short Term): Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.

Research Area: Ion Channels

Restrictions: For Research Use only

Images

WB Suggested Anti-SCNN1B Antibody Titration: 0.125ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysate

Publications

Product: Snyder, Olson, Kabra et al.: "cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 45753-8, 2004 (PubMed).