VDAC1 antibody (C-Term)

Catalog No. ABIN183134

There are 3+ publications for this product available. The Rabbit Polyclonal anti-VDAC1 antibody is suitable to detect VDAC1 in samples from Human, Rat, Mouse, Rabbit, Cow, Dog, Sheep, Horse, Guinea Pig and Zebrafish (Danio rerio). It has been validated for WB and IHC.

Quick Overview for VDAC1 antibody (C-Term) (ABIN183134)

Target: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Reactivity: Human, Rat, Mouse, Rabbit, Cow, Dog, Sheep, Horse, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VDAC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-VDAC1 Antibody

Binding Specificity: C-Term

Sequence: SAKVNNSSLI GLGYTQTLKP GIKLTLSALL DGKNVNAGGH KLGLGLEFQA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against VDAC1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human VDAC1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 283 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-VDAC1 antibody (ABIN183134)

Rousset, Nguyen, Grange, Morel, Lardy: "Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes." in: PLoS ONE, Vol. 8, Issue 6, pp. e66478, (2013) (PubMed).

Arduíno, Esteves, Cortes, Silva, Patel, Grazina, Swerdlow, Oliveira, Cardoso: "Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic." in: Human molecular genetics, Vol. 21, Issue 21, pp. 4680-702, (2012) (PubMed).

Chen, Martin, Maya-Mendoza, Tang, Lovri?, Sims, Jackson: "Reduced expression of lamin A/C results in modified cell signaling and metabolism coupled with changes in expression of structural proteins." in: Journal of proteome research, Vol. 8, Issue 11, pp. 5196-211, (2009) (PubMed).

Target Details for VDAC1

Target: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Alternative Name: VDAC1

Background: The voltage-dependent anion-selective channel 1 (VDAC1) functions as a channel in membranous structures for the outer mitochondrial membrane, the cell membrane, endosomes, caveolae, the sarcoplasmatic reticulum, synaptosomes, and post-synaptic density fraction. A major function of VDAC1 in the plasma membrane is that of a NADH(-ferricyanide) reductase that may be involved in the maintenance of cellular redox homeostasis.
Alias Symbols: PORIN, VDAC-1
Protein Interaction Partner: UBC, KLHL40, SPRTN, MDM2, ADRB2, ASB14, ASB17, PARK2, BAG3, env, VCAM1, HK1, ATF2, FMNL1, TUBA1B, MDC1, CAV1, Htt, SFXN3, SUGP1, UBAP2, UFM1, ACAD9, MGAT4B, ACAA2, ZMPSTE24, VAPA, ALDH5A1, SF1, VDAC3, VDAC2, UBA52, TIAL1, FLOT2, CDK2, SIRT7, SUMO4, MAPK3,
Protein Size: 283

Molecular Weight: 31 kDa

Gene ID: 7416

NCBI Accession: NM_003374, NP_003365

UniProt: Q5FVE7