JMJD2D antibody (C-Term)

Catalog No. ABIN183251

The Rabbit Polyclonal anti-JMJD2D antibody has been validated for WB. It is suitable to detect JMJD2D in samples from Human. There are 2+ publications available.

Quick Overview for JMJD2D antibody (C-Term) (ABIN183251)

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JMJD2D antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-JMJD2D Antibody

Binding Specificity: C-Term

Sequence: SSTPGPSAQI IHPSNGRRGR GRPPQKLRAQ ELTLQTPAKR PLLAGTTCTA

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against JMJD2D. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human JMJD2D

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 523 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-JMJD2D antibody (ABIN183251)

Kim, Fuchs, Schwartz, Abdelhamid, Etter, Berry, Li, Ihnat, Li, Janknecht: "Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors." in: American journal of translational research, Vol. 6, Issue 3, pp. 236-47, (2014) (PubMed).

Kim, Oh, Shin, Janknecht: "Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D." in: PLoS ONE, Vol. 7, Issue 4, pp. e34618, (2012) (PubMed).

Target Details for JMJD2D

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Alternative Name: JMJD2D

Background: JMJD2D belongs to JMJD2 family that is consist of four cancer-associated genes
Alias Symbols: JMJD2D
Protein Interaction Partner: HECW2, PPP1CC, CUL4B, TP53, AR, KDM4D,
Protein Size: 523

Molecular Weight: 59 kDa

Gene ID: 55693

NCBI Accession: NM_018039, NP_060509

UniProt: Q6B0I6

Pathways: Warburg Effect