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JMJD2D antibody

KDM4D Reactivity: Human, Rat, Mouse ELISA, WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7002265
  • Target See all JMJD2D (KDM4D) Antibodies
    JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))
    Reactivity
    Human, Rat, Mouse
    Host
    • 33
    Rabbit
    Clonality
    • 33
    Polyclonal
    Conjugate
    • 16
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This JMJD2D antibody is un-conjugated
    Application
    • 22
    • 17
    • 4
    • 3
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant protein of human KDM4D
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.2 mg/mL
    Buffer
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))
    Alternative Name
    KDM4D (KDM4D Products)
    Synonyms
    JMJD2D antibody, 4932416A15 antibody, Jmjd2d antibody, KDM4D antibody, lysine demethylase 4D antibody, lysine-specific demethylase 4D antibody, lysine (K)-specific demethylase 4D antibody, KDM4D antibody, LOC524768 antibody, Kdm4d antibody, LOC617971 antibody, LOC100067461 antibody, LOC698455 antibody, LOC100514356 antibody
    Background
    JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.
    Molecular Weight
    59 kDa
    UniProt
    Q6B0I6
    Pathways
    Warburg Effect
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