TFEB antibody (C-Term)

Catalog No. ABIN183717

The Rabbit Polyclonal anti-TFEB antibody (ABIN183717) specifically detects TFEB in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Horse, Goat, Rabbit, Guinea Pig, Saccharomyces cerevisiae, Sheep and Zebrafish (Danio rerio) samples.

Quick Overview for TFEB antibody (C-Term) (ABIN183717)

Target: TFEB (Transcription Factor EB (TFEB))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Goat, Rabbit, Guinea Pig, Saccharomyces cerevisiae, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFEB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TFEB Antibody

Binding Specificity: C-Term

Purpose: TFEB Antibody - C-terminal region

Sequence: SLSKKDLDLM LLDDSLLPLA SDPLLSTMSP EASKASSRRS SFSMEEGDVL

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 85%, Yeast: 100%, Zebrafish: 91%

Characteristics: This is a rabbit polyclonal antibody against TFEB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TFEB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38810-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TFEB

Target: TFEB (Transcription Factor EB (TFEB))

Alternative Name: TFEB

Background:

Background Information: TFEB is a member of the basic Helix-Loop-Helix-Zipper family of transcription factors. TFEB can bind DNA as a homodimer or as a heterodimer with three closely related family members: MITF, TFE3 and TFEC. The t(6,11)(p21,q12), a translocation recently been shown to result in fusion of Alpha, a gene on 11q12, with the transcription factor gene TFEB on 6p21.This translocation ultimately leads to the development of Renal carcinomas.

Gene Name: Transcription factor EB

Alternative Symbols: TCFEB, BHLHE35, ALPHATFEB

Protein Name: Transcription factor EB

Molecular Weight: 53kDa

Gene ID: 7942

NCBI Accession: NP_009093

UniProt: P19484